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Pira1 paired-Ig-like receptor A1 [ Mus musculus (house mouse) ]

Gene ID: 18722, updated on 2-Nov-2024

Summary

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Official Symbol
Pira1provided by MGI
Official Full Name
paired-Ig-like receptor A1provided by MGI
Primary source
MGI:MGI:1195971
See related
Ensembl:ENSMUSG00000081665 AllianceGenome:MGI:1195971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pir; 6M21; Ly89; PIR-A1; Gm15922
Summary
Predicted to be involved in negative regulation of osteoclast differentiation. Orthologous to human LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 12.1), mammary gland adult (RPKM 5.4) and 13 other tissues See more
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Genomic context

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See Pira1 in Genome Data Viewer
Location:
7 A1; 7 2.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3734625..3742957, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3731626..3739943, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9 Neighboring gene STARR-positive B cell enhancer mm9_chr7:3672088-3672388 Neighboring gene paired Ig-like receptor B Neighboring gene paired-Ig-like receptor A2, pseudogene 2 Neighboring gene paired-Ig-like receptor A2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Paired immunoglobulin-like receptors and their MHC class I recognition. Takai T. Immunology, 2005 Aug. PMID 16011512, Free PMC Article
  2. PIR-B-deficient mice are susceptible to Salmonella infection. Torii I, et al. J Immunol, 2008 Sep 15. PMID 18768880, Free PMC Article
  3. Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development. Ben Baruch-Morgenstern N, et al. Nat Immunol, 2014 Jan. PMID 24212998, Free PMC Article
  4. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624
  5. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Kasahara M, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370446, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate a critical role for PIR-B and PIR-A in eosinophil development.
    Title: Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.
  2. Disruption of paired immunoglobulin-like activating (PIR-A) and inhibitory (PIR-B) receptor isoform balance affects their regulatory roles in host defense during Salmonella infection.
    Title: PIR-B-deficient mice are susceptible to Salmonella infection.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
paired-Ig-like receptor A1
Names
paired immunoglobulin-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371068.1 → NP_001357997.1  paired-Ig-like receptor A1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/TrEMBL
    A2NTK2
    Conserved Domains (1) summary
    cl11960
    Location:123 → 219
    Ig; Immunoglobulin domain

RNA

  1. NR_163846.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Related
    ENSMUST00000118068.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3734625..3742957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152778.1 → XP_036008671.1  paired-Ig-like receptor A1 isoform X1

    UniProtKB/TrEMBL
    A2NTK2
    Conserved Domains (2) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cl11960
    Location:129 → 225
    Ig; Immunoglobulin domain

  2. XM_017322037.3 → XP_017177526.1  paired-Ig-like receptor A1 isoform X2

    UniProtKB/TrEMBL
    A2NTK2
    Conserved Domains (1) summary
    cl11960
    Location:28 → 124
    Ig; Immunoglobulin domain

  3. XM_036152779.1 → XP_036008672.1  paired-Ig-like receptor A1 isoform X3

    UniProtKB/TrEMBL
    A2NTK2
    Conserved Domains (2) summary
    cd00096
    Location:35 → 39
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 123
    Ig; Immunoglobulin domain

  4. XM_036152780.1 → XP_036008673.1  paired-Ig-like receptor A1 isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cl11960
    Location:129 → 225
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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