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Prim1 DNA primase, p49 subunit [ Mus musculus (house mouse) ]

Gene ID: 19075, updated on 14-Nov-2024

Summary

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Official Symbol
Prim1provided by MGI
Official Full Name
DNA primase, p49 subunitprovided by MGI
Primary source
MGI:MGI:97757
See related
Ensembl:ENSMUSG00000025395 AllianceGenome:MGI:97757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA primase activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM1 (DNA primase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 29.4), CNS E11.5 (RPKM 24.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Prim1 in Genome Data Viewer
Location:
10 76.39 cM; 10 D3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127851084..127865899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128015215..128030030)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 6 Neighboring gene STARR-positive B cell enhancer ABC_E8376 Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene prostaglandin E synthase 3 Neighboring gene predicted gene, 47438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse primase p49 subunit molecular cloning indicates conserved and divergent regions. Prussak CE, et al. J Biol Chem, 1989 Mar 25. PMID 2925677
  2. Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit. Mizuno T, et al. J Cell Sci, 1996 Nov. PMID 8937981
  3. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Adler DA, et al. Genomics, 1991 Apr. PMID 2037291
  4. Molecular cloning of the cDNAs for the four subunits of mouse DNA polymerase alpha-primase complex and their gene expression during cell proliferation and the cell cycle. Miyazawa H, et al. J Biol Chem, 1993 Apr 15. PMID 8463324
  5. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. Shiratori A, et al. Genomics, 1995 Jul 20. PMID 8530050

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107288

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA primase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA primase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication, synthesis of primer ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alpha DNA polymerase:primase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of alpha DNA polymerase:primase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA primase small subunit
Names
DNA primase 49 kDa subunit
p49
NP_032947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008921.2 → NP_032947.1  DNA primase small subunit

    See identical proteins and their annotated locations for NP_032947.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131120
    Consensus CDS
    CCDS36086.1
    UniProtKB/Swiss-Prot
    P20664
    UniProtKB/TrEMBL
    Q3UZF0, Q5FW94
    Related
    ENSMUSP00000026461.8, ENSMUST00000026461.8
    Conserved Domains (1) summary
    cd04860
    Location:26 → 343
    AE_Prim_S; AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127851084..127865899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20664.1 GenPept UniProtKB/Swiss-Prot:P20664

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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