U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [ Mus musculus (house mouse) ]

Gene ID: 19188, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Psme2provided by MGI
Official Full Name
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)provided by MGI
Primary source
MGI:MGI:1096365
See related
Ensembl:ENSMUSG00000079197 AllianceGenome:MGI:1096365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA28b
Summary
Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and pancreas. Orthologous to human PSME2 (proteasome activator subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 78.6), duodenum adult (RPKM 27.9) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Psme2 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55824897..55828558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55587440..55591101, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9 Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene ring finger protein 31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy.
    Title: PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.
  2. Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species.
    Title: The Mammalian Proteasome Activator PA28 Forms an Asymmetric α(4)β(3) Complex.
  3. Increased PA28B expression is associated with viral myocarditis.
    Title: PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
  4. Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.
    Title: Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
  5. demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides
    Title: PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.
  6. PA28-associated proteasome preferentially digested within epitopic sequences of K(d), although correct C-terminal flankings were removed
    Title: Allele-selective effect of PA28 in MHC class I antigen processing.
  7. An alternative splice pattern of the Psme2 (PA28b) gene, which encodes the beta subunit of the proteasome activator PA28, is characterized.
    Title: Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes.
  8. the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90
    Title: Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to endopeptidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome activator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
proteasome activator complex subunit 2
Names
11S regulator complex subunit beta
PA28beta
REG-beta
activator of multicatalytic protease subunit 2
protease (prosome, macropain) 28 subunit, beta
proteasome (prosome, macropain) 28 subunit, beta
proteasome activator 28 subunit beta

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029855.1 → NP_001025026.1  proteasome activator complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001025026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate transcription initiation site and uses a distinct start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA216967, AA267668, AK012344, BB869062
    Consensus CDS
    CCDS49495.1
    UniProtKB/TrEMBL
    G3X9V0
    Related
    ENSMUSP00000107009.4, ENSMUST00000111378.10
    Conserved Domains (2) summary
    pfam02251
    Location:9 → 57
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:88 → 229
    PA28_beta; Proteasome activator pa28 beta subunit

  2. NM_011190.3 → NP_035320.1  proteasome activator complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_035320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA216967, AK012344, BU563130, BY134400, BY498670, CA536627
    Consensus CDS
    CCDS49494.1
    UniProtKB/Swiss-Prot
    O35562, P97372
    UniProtKB/TrEMBL
    A0A1G5SJA5, Q5SVP3
    Related
    ENSMUSP00000123798.2, ENSMUST00000161807.8
    Conserved Domains (2) summary
    pfam02251
    Location:12 → 66
    PA28_alpha; Proteasome activator pa28 alpha subunit
    pfam02252
    Location:94 → 235
    PA28_beta; Proteasome activator pa28 beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55824897..55828558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97372.4 GenPept UniProtKB/Swiss-Prot:P97372

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous