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ddx19b DEAD-box helicase 19b [ Danio rerio (zebrafish) ]

Gene ID: 192339, updated on 2-Nov-2024

Summary

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Official Symbol
ddx19bprovided by ZNC
Official Full Name
DEAD-box helicase 19bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-30
See related
Ensembl:ENSDARG00000005699 AllianceGenome:ZFIN:ZDB-GENE-020419-30
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ddx19; fi21a04; chunp6915; wu:fb24g07; wu:fc59e08; wu:fd14f03; wu:fi21a04
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be active in cytoplasmic stress granule and nucleus. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ddx19b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3524737..3535500, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3505350..3516113, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3b Neighboring gene pseudouridine synthase like 1 Neighboring gene si:dkey-33m11.7 Neighboring gene calcium/calmodulin dependent protein kinase II inhibitor 1 Neighboring gene si:dkey-33m11.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Jao LE, et al. Proc Natl Acad Sci U S A, 2013 Aug 20. PMID 23918387, Free PMC Article
  2. Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. von Moeller H, et al. Nucleic Acids Res, 2013 Sep. PMID 23804756, Free PMC Article
  3. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19B
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)
DEAD/H box polypeptide 19
NP_775365.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173258.1 → NP_775365.1  ATP-dependent RNA helicase DDX19B

    See identical proteins and their annotated locations for NP_775365.1

    Status: PROVISIONAL

    Source sequence(s)
    AY099536
    UniProtKB/TrEMBL
    Q7ZU28, Q8JGR1
    Related
    ENSDARP00000003250.4, ENSDART00000009788.7
    Conserved Domains (3) summary
    PTZ00424
    Location:99 → 477
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:315 → 450
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:102 → 304
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3524737..3535500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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