Ptprk protein tyrosine phosphatase receptor type K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprkprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Kprovided by MGI
Primary source: MGI:MGI:103310
See related: Ensembl:ENSMUSG00000019889 AllianceGenome:MGI:103310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTPk; RPTPkappa
Summary: Enables protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in several cellular components, including dendrite; neuronal cell body; and photoreceptor outer segment. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 11.3), CNS E18 (RPKM 10.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 15.06 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (27950406..28473393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (28074820..28597397)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study show that RAS at the Golgi is selectively activated by apoptogenic stimuli and antagonizes cell survival by suppressing ERK activity through the induction of PTPRkappa, which targets CRAF for dephosphorylation. RAS oncogenic potential is strictly dependent on its sublocalization, with Golgi complex-located RAS antagonizing tumor development.
Title: RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation.
RPTP-kappa is proteolytically processed to isoforms that have opposing effects on beta-catenin activity.
Title: The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI853699 (e-PCR)
- UniSTS:180021

Ptprk (e-PCR), detects polymorphism
- UniSTS:536490

L10106 (e-PCR)
- UniSTS:124871

BB188282 (e-PCR)
- UniSTS:185822

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in leading edge membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase kappa

Names: R-PTP-kappa; protein-tyrosine phosphatase kappa

NP_001346284.1

EC 3.1.3.48

NP_001346285.1

EC 3.1.3.48

NP_033009.1

EC 3.1.3.48

XP_006512669.1

EC 3.1.3.48

XP_006512670.1

EC 3.1.3.48

XP_006512671.1

EC 3.1.3.48

XP_006512673.1

EC 3.1.3.48

XP_006512674.1

EC 3.1.3.48

XP_006512675.1

EC 3.1.3.48

XP_006512677.1

EC 3.1.3.48

XP_006512678.1

EC 3.1.3.48

XP_006512680.1

EC 3.1.3.48

XP_006512681.1

EC 3.1.3.48

XP_006512682.1

EC 3.1.3.48

XP_011241445.1

EC 3.1.3.48

XP_011241446.1

EC 3.1.3.48

XP_011241447.1

EC 3.1.3.48

XP_011241448.1

EC 3.1.3.48

XP_017169339.1

EC 3.1.3.48

XP_030100820.1

EC 3.1.3.48

XP_036011592.1

EC 3.1.3.48

XP_036011593.1

EC 3.1.3.48

XP_036011594.1

EC 3.1.3.48

XP_036011595.1

EC 3.1.3.48

XP_036011596.1

EC 3.1.3.48

XP_036011597.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359355.2 → NP_001346284.1 receptor-type tyrosine-protein phosphatase kappa isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504

Consensus CDS

CCDS87975.1

UniProtKB/TrEMBL

A0A1W2P7Y1

Related

ENSMUSP00000151866.2, ENSMUST00000218276.2

Conserved Domains (4) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd00047
Location:939 → 1172

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain
NM_001359356.2 → NP_001346285.1 receptor-type tyrosine-protein phosphatase kappa isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504

Consensus CDS

CCDS87976.1

UniProtKB/TrEMBL

B2RRF0

Related

ENSMUSP00000151986.2, ENSMUST00000218359.2

Conserved Domains (4) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd00047
Location:913 → 1146

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain
NM_001428766.1 → NP_001415695.1 receptor-type tyrosine-protein phosphatase kappa isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504
NM_001428767.1 → NP_001415696.1 receptor-type tyrosine-protein phosphatase kappa isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504
NM_001428768.1 → NP_001415697.1 receptor-type tyrosine-protein phosphatase kappa isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504
NM_001428769.1 → NP_001415698.1 receptor-type tyrosine-protein phosphatase kappa isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504
NM_008983.3 → NP_033009.1 receptor-type tyrosine-protein phosphatase kappa isoform 2 precursor

See identical proteins and their annotated locations for NP_033009.1

Status: VALIDATED

Source sequence(s)

AC129772, AC152983, AC153972, AC158646, AC159504

Consensus CDS

CCDS35874.1

UniProtKB/Swiss-Prot

P35822

Related

ENSMUSP00000126279.2, ENSMUST00000166468.2

Conserved Domains (9) summary

cd06263
Location:35 → 191

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:898 → 1158

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd00047
Location:925 → 1158

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:487 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:293 → 371

fn3; Fibronectin type III domain

pfam00102
Location:1218 → 1452

Y_phosphatase; Protein-tyrosine phosphatase

cl11960
Location:203 → 283

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

27950406..28473393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243143.4 → XP_011241445.1 receptor-type tyrosine-protein phosphatase kappa isoform X5

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1260 → 1465

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:896 → 1174

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011243146.4 → XP_011241448.1 receptor-type tyrosine-protein phosphatase kappa isoform X23

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1254 → 1459

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:896 → 1168

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155700.1 → XP_036011593.1 receptor-type tyrosine-protein phosphatase kappa isoform X8

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1256 → 1461

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cl28904
Location:892 → 1170

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512606.4 → XP_006512669.1 receptor-type tyrosine-protein phosphatase kappa isoform X1

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1275 → 1480

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:911 → 1189

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512608.5 → XP_006512671.1 receptor-type tyrosine-protein phosphatase kappa isoform X4

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1269 → 1474

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:911 → 1183

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512607.4 → XP_006512670.1 receptor-type tyrosine-protein phosphatase kappa isoform X3

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1271 → 1476

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:907 → 1185

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512610.4 → XP_006512673.1 receptor-type tyrosine-protein phosphatase kappa isoform X6

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1259 → 1464

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:895 → 1173

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512611.5 → XP_006512674.1 receptor-type tyrosine-protein phosphatase kappa isoform X9

Conserved Domains (6) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd00063
Location:487 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14636
Location:1253 → 1458

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:296 → 370

fn3; Fibronectin type III domain

cl28904
Location:895 → 1167

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155699.1 → XP_036011592.1 receptor-type tyrosine-protein phosphatase kappa isoform X7

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1257 → 1462

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cl28904
Location:893 → 1171

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155701.1 → XP_036011594.1 receptor-type tyrosine-protein phosphatase kappa isoform X11

Conserved Domains (6) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd14636
Location:1251 → 1456

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cd00096
Location:209 → 219

Ig; Ig strand B [structural motif]

cl28904
Location:893 → 1165

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155703.1 → XP_036011596.1 receptor-type tyrosine-protein phosphatase kappa isoform X14

Conserved Domains (6) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd14636
Location:1245 → 1450

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cd00096
Location:209 → 219

Ig; Ig strand B [structural motif]

cl28904
Location:881 → 1159

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512612.4 → XP_006512675.1 receptor-type tyrosine-protein phosphatase kappa isoform X10

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1251 → 1456

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:887 → 1165

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030244960.2 → XP_030100820.1 receptor-type tyrosine-protein phosphatase kappa isoform X15

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1241 → 1446

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:883 → 1155

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512614.5 → XP_006512677.1 receptor-type tyrosine-protein phosphatase kappa isoform X17

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1229 → 1434

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:871 → 1143

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_017313850.3 → XP_017169339.1 receptor-type tyrosine-protein phosphatase kappa isoform X2

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1274 → 1479

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:910 → 1188

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011243144.4 → XP_011241446.1 receptor-type tyrosine-protein phosphatase kappa isoform X12

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1250 → 1455

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:886 → 1164

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155702.1 → XP_036011595.1 receptor-type tyrosine-protein phosphatase kappa isoform X13

Conserved Domains (6) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00410
Location:201 → 287

IG_like; Immunoglobulin like

cd14636
Location:1246 → 1451

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cd00096
Location:209 → 219

Ig; Ig strand B [structural motif]

cl28904
Location:882 → 1160

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036155704.1 → XP_036011597.1 receptor-type tyrosine-protein phosphatase kappa isoform X16

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1240 → 1445

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 582

fn3; Fibronectin type III domain

cl28904
Location:882 → 1154

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512615.5 → XP_006512678.1 receptor-type tyrosine-protein phosphatase kappa isoform X18

Conserved Domains (5) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

cd14636
Location:1228 → 1433

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain

cl28904
Location:870 → 1142

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006512618.5 → XP_006512681.1 receptor-type tyrosine-protein phosphatase kappa isoform X20

UniProtKB/TrEMBL

Q8C462

Conserved Domains (3) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain
XM_011243145.4 → XP_011241447.1 receptor-type tyrosine-protein phosphatase kappa isoform X21

UniProtKB/TrEMBL

Q8C462

Conserved Domains (3) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain
XM_006512619.4 → XP_006512682.1 receptor-type tyrosine-protein phosphatase kappa isoform X22

UniProtKB/TrEMBL

Q8C462

Conserved Domains (3) summary

smart00137
Location:31 → 191

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:201 → 287

IG; Immunoglobulin

pfam00041
Location:487 → 580

fn3; Fibronectin type III domain
XM_006512617.2 → XP_006512680.1 receptor-type tyrosine-protein phosphatase kappa isoform X19

Conserved Domains (5) summary

smart00137
Location:1 → 115

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00409
Location:125 → 211

IG; Immunoglobulin

cd14636
Location:1199 → 1404

R-PTPc-K-2; PTP domain of receptor-type tyrosine-protein phosphatase K, repeat 2

pfam00041
Location:411 → 504

fn3; Fibronectin type III domain

cl28904
Location:835 → 1113

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily