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Rab22a RAB22A, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19334, updated on 18-Sep-2024

Summary

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Official Symbol
Rab22aprovided by MGI
Official Full Name
RAB22A, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105072
See related
Ensembl:ENSMUSG00000027519 AllianceGenome:MGI:105072
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab22; 3732413A17Rik; E130120E14Rik
Summary
Enables GTP binding activity and GTPase activity. Predicted to be involved in endocytosis; intracellular protein transport; and regulation of vesicle size. Predicted to act upstream of or within protein transport. Located in actin cytoskeleton. Orthologous to human RAB22A (RAB22A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 24.0), testis adult (RPKM 24.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rab22a in Genome Data Viewer
Location:
2 H4; 2 97.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (173501638..173543975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (173659836..173702186)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 60 Neighboring gene protein phosphatase 4, regulatory subunit 1-like, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8799 Neighboring gene STARR-positive B cell enhancer ABC_E7891 Neighboring gene STARR-positive B cell enhancer ABC_E648 Neighboring gene microRNA 6340 Neighboring gene RIKEN cDNA 1700010B08 gene Neighboring gene STARR-positive B cell enhancer ABC_E1610 Neighboring gene vesicle-associated membrane protein, associated protein B and C Neighboring gene adenomatosis polyposis coli down-regulated 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells. Cebrian I, et al. EMBO Rep, 2016 Dec. PMID 27861124, Free PMC Article
  2. Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity. Gao Y, et al. Cell Res, 2022 Dec. PMID 36280710, Free PMC Article
  3. Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. Shakya S, et al. EMBO Rep, 2018 Dec. PMID 30404817, Free PMC Article
  4. Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. Olkkonen VM, et al. J Cell Sci, 1993 Dec. PMID 8126105
  5. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
    Title: Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
  2. Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on early/sorting endosomes.
    Title: Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes.
  3. findings provide compelling evidence that Rab22a plays a central role in the MHC-I endocytic trafficking, which is crucial for efficient cross-presentation by dendritic cells
    Title: Rab22a controls MHC-I intracellular trafficking and antigen cross-presentation by dendritic cells.
  4. Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
    Title: Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vesicle size IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of vesicle size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-22A
Names
RAB22, member RAS oncogene family
rab-14
rab-22
NP_077756.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024436.3 → NP_077756.2  ras-related protein Rab-22A

    See identical proteins and their annotated locations for NP_077756.2

    Status: PROVISIONAL

    Source sequence(s)
    AK146594
    Consensus CDS
    CCDS38352.1
    UniProtKB/Swiss-Prot
    P35285, Q3UCA7, Q91VD4
    UniProtKB/TrEMBL
    Q0PD34, Q9CXG2
    Related
    ENSMUSP00000029024.4, ENSMUST00000029024.10
    Conserved Domains (1) summary
    cd01860
    Location:5 → 167
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    173501638..173543975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35285.2 GenPept UniProtKB/Swiss-Prot:P35285

Gene LinkOut

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