Tmprss11a transmembrane protease, serine 11a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss11aprovided by MGI
Official Full Name: transmembrane protease, serine 11aprovided by MGI
Primary source: MGI:MGI:2684853
See related: Ensembl:ENSMUSG00000072845 AllianceGenome:MGI:2684853
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm7
Summary: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within viral entry into host cell. Predicted to be located in extracellular region and membrane. Predicted to be integral component of plasma membrane. Is expressed in bladder; eye; foregut; male reproductive gland or organ; and pituitary gland. Orthologous to human TMPRSS11A (transmembrane serine protease 11A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86558269..86617034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86410410..86469175, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that TMPRSS11A, another member of the TTSP family, cleaves and activates the influenza A virus (FLUAV) HA and the Middle East respiratory syndrome coronavirus spike protein (MERS-S).
Title: TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.
A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed.
Title: Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tmprss11a (e-PCR), detects polymorphism
- UniSTS:495947

NoName (e-PCR)
- UniSTS:235208

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within symbiont entry into host cell	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 11A

Names: DESC-3; airway trypsin-like protease 1; serine protease DESC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033233.2 → NP_001028405.1 transmembrane protease serine 11A

See identical proteins and their annotated locations for NP_001028405.1

Status: PROVISIONAL

Source sequence(s)

AK142820

Consensus CDS

CCDS51531.1

UniProtKB/Swiss-Prot

Q3UQ41

Related

ENSMUSP00000098634.3, ENSMUST00000101073.3

Conserved Domains (3) summary

smart00020
Location:157 → 383

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:158 → 386

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:39 → 128

SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

86558269..86617034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534840.2 → XP_006534903.1 transmembrane protease serine 11A isoform X1

Conserved Domains (2) summary

cd00190
Location:161 → 389

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:42 → 135

SEA; SEA domain