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lmna lamin A [ Danio rerio (zebrafish) ]

Gene ID: 195815, updated on 15-Dec-2024

Summary

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Official Symbol
lmnaprovided by ZNC
Official Full Name
lamin Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020424-3
See related
Ensembl:ENSDARG00000013415 AllianceGenome:ZFIN:ZDB-GENE-020424-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb948; wu:fk66d12
Summary
Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within several processes, including heart contraction; regulation of cellular senescence; and skeletal muscle tissue development. Predicted to be located in intermediate filament; nuclear matrix; and nucleoplasm. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in several structures, including fin; head; mesoderm; musculature system; and pleuroperitoneal region. Used to study muscle tissue disease. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See lmna in Genome Data Viewer
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30521632..30569571, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30562930..30611687, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 7 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene melanocortin 2 receptor Neighboring gene melanocortin 5b receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of tissue-specific regulatory region in the zebrafish lamin A promoter. Verma AD, et al. Gene, 2015 Aug 1. PMID 25921963
  2. Specific RNAi mediated gene knockdown in zebrafish cell lines. Gruber J, et al. RNA Biol, 2005 Jul-Sep. PMID 17114924
  3. Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases. Hayashi K, et al. Cardiovasc Res, 2020 Nov 1. PMID 31977013, Free PMC Article
  4. Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9. Prykhozhij SV, et al. Nucleic Acids Res, 2018 Sep 28. PMID 29905858, Free PMC Article
  5. Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina. Amini R, et al. Elife, 2022 May 31. PMID 35639083, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear lamina IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lamin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152971.1 → NP_694503.1  lamin

    See identical proteins and their annotated locations for NP_694503.1

    Status: PROVISIONAL

    Source sequence(s)
    AF397016
    UniProtKB/TrEMBL
    Q90XD7
    Related
    ENSDARP00000153174.1, ENSDART00000191716.1
    Conserved Domains (6) summary
    pfam00038
    Location:27 → 383
    Filament; Intermediate filament protein
    pfam00932
    Location:451 → 559
    LTD; Lamin Tail Domain
    pfam02601
    Location:322 → 400
    Exonuc_VII_L; Exonuclease VII, large subunit
    pfam04871
    Location:102 → 202
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam06156
    Location:295 → 359
    DUF972; Protein of unknown function (DUF972)
    cl12013
    Location:237 → 350
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    30521632..30569571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158168.5 → XP_005158225.1  lamin isoform X1

    See identical proteins and their annotated locations for XP_005158225.1

    UniProtKB/TrEMBL
    B3DKC5, B3DKD3
    Related
    ENSDARP00000145959.1, ENSDART00000191040.1
    Conserved Domains (6) summary
    pfam00038
    Location:27 → 383
    Filament; Intermediate filament protein
    pfam00932
    Location:451 → 559
    LTD; Lamin Tail Domain
    pfam02601
    Location:322 → 400
    Exonuc_VII_L; Exonuclease VII, large subunit
    pfam04871
    Location:102 → 202
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam06156
    Location:295 → 359
    DUF972; Protein of unknown function (DUF972)
    cl12013
    Location:237 → 350
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_005158167.5 → XP_005158224.1  lamin isoform X1

    See identical proteins and their annotated locations for XP_005158224.1

    UniProtKB/TrEMBL
    B3DKC5, B3DKD3
    Related
    ENSDARP00000113049.1, ENSDART00000145087.2
    Conserved Domains (6) summary
    pfam00038
    Location:27 → 383
    Filament; Intermediate filament protein
    pfam00932
    Location:451 → 559
    LTD; Lamin Tail Domain
    pfam02601
    Location:322 → 400
    Exonuc_VII_L; Exonuclease VII, large subunit
    pfam04871
    Location:102 → 202
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam06156
    Location:295 → 359
    DUF972; Protein of unknown function (DUF972)
    cl12013
    Location:237 → 350
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version

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