Rpa2 replication protein A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpa2provided by MGI
Official Full Name: replication protein A2provided by MGI
Primary source: MGI:MGI:1339939
See related: Ensembl:ENSMUSG00000028884 AllianceGenome:MGI:1339939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPA34; Rf-A2
Summary: Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Predicted to be located in PML body and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; heart; and spermatocyte. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14 (RPKM 35.0), liver E14.5 (RPKM 32.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 65.88 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132495671..132506057)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132768360..132778746)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124820 (e-PCR)
- UniSTS:161642

AI325195 (e-PCR)
- UniSTS:179081

RH136338 (e-PCR)
- UniSTS:210328

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables G-rich strand telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in mismatch repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G1 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic G1 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to chromosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DNA replication factor A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA replication factor A complex	ISO Inferred from Sequence Orthology more info
part_of DNA replication factor A complex	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with site of double-strand break	ISO Inferred from Sequence Orthology more info
colocalizes_with site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: replication protein A 32 kDa subunit

Names: 30-kDa protein; RF-A protein 2; RP-A p32; RP-A p34; replication factor A protein 2; replication protein A 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429787.1 → NP_001416716.1 replication protein A 32 kDa subunit isoform 2

Status: VALIDATED

Source sequence(s)

AL627130

UniProtKB/TrEMBL

Q99KL9
NM_011284.4 → NP_035414.3 replication protein A 32 kDa subunit isoform 1

See identical proteins and their annotated locations for NP_035414.3

Status: VALIDATED

Source sequence(s)

AL627130

Consensus CDS

CCDS18734.1

UniProtKB/Swiss-Prot

Q3TE40, Q62193

UniProtKB/TrEMBL

Q99KL9

Related

ENSMUSP00000099621.5, ENSMUST00000102561.11

Conserved Domains (3) summary

COG5235
Location:6 → 267

RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]

cd04478
Location:73 → 167

RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...

pfam08784
Location:166 → 262

RPA_C; Replication protein A C terminal