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Polr1c polymerase (RNA) I polypeptide C [ Mus musculus (house mouse) ]

Gene ID: 20016, updated on 9-Dec-2024

Summary

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Official Symbol
Polr1cprovided by MGI
Official Full Name
polymerase (RNA) I polypeptide Cprovided by MGI
Primary source
MGI:MGI:103288
See related
Ensembl:ENSMUSG00000067148 AllianceGenome:MGI:103288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
40kDa; RPA40; Polr1e; Rpo1-1
Summary
Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; genitourinary system; midbrain; respiratory system; and telencephalon. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 45.3), limb E14.5 (RPKM 32.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Polr1c in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46554846..46558971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46243920..46248045, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene exportin 5 Neighboring gene microRNA 693 Neighboring gene predicted gene, 22474 Neighboring gene STARR-positive B cell enhancer ABC_E11645 Neighboring gene Yip1 domain family, member 3 Neighboring gene leucine rich repeat containing 73

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High conservation of subunit composition of RNA polymerase I(A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. Song CZ, et al. J Biol Chem, 1994 Oct 28. PMID 7929437
  2. Isolation and characterization of cDNA encoding mouse RNA polymerase II subunit RPB14. Nishi Y, et al. Gene, 1997 Mar 18. PMID 9099876
  3. Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I. Seither P, et al. Genomics, 1996 Oct 1. PMID 8921381
  4. Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development. Falcon KT, et al. Proc Natl Acad Sci U S A, 2022 Aug 2. PMID 35881792, Free PMC Article
  5. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC161175

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase I activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase III activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerases I and III subunit RPAC1
Names
AC40
DNA-directed RNA polymerase I subunit C
DNA-directed RNA polymerases I and III 40 kDa polypeptide
RNA polymerase 1-1 (40 kDa subunit)
RNA polymerases I and III subunit AC1
RPC40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009085.2 → NP_033111.2  DNA-directed RNA polymerases I and III subunit RPAC1

    See identical proteins and their annotated locations for NP_033111.2

    Status: VALIDATED

    Source sequence(s)
    AK132114, BY267923, CJ207889
    Consensus CDS
    CCDS37632.1
    UniProtKB/Swiss-Prot
    P52432, Q3UJZ9
    UniProtKB/TrEMBL
    A1L3C2
    Related
    ENSMUSP00000084252.7, ENSMUST00000087026.13
    Conserved Domains (2) summary
    cd07032
    Location:49 → 339
    RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    smart00662
    Location:61 → 336
    RPOLD; RNA polymerases D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46554846..46558971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52432.3 GenPept UniProtKB/Swiss-Prot:P52432

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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