U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDY2B chromodomain Y-linked 2B [ Homo sapiens (human) ]

Gene ID: 203611, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CDY2Bprovided by HGNC
Official Full Name
chromodomain Y-linked 2Bprovided by HGNC
Primary source
HGNC:HGNC:23921
See related
Ensembl:ENSG00000129873 AllianceGenome:HGNC:23921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDY
Summary
This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CDY2B in Genome Data Viewer
Location:
Yq11.222
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (17878260..17880220, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (18784818..18786778, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (19990140..19992100, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene OFD1 pseudogene 1 Y-linked Neighboring gene elongin C pseudogene 6 Neighboring gene chromodomain Y-linked 6 pseudogene Neighboring gene USP9Y pseudogene 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A fiber-FISH contig spanning the non-recombining region of the human Y chromosome. Röttger S, et al. Chromosome Res, 2002. PMID 12575791
  2. Comparative mapping of CDY and DAZ in higher primates. Wimmer R, et al. Cytogenet Genome Res, 2002. PMID 12438810
  3. Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family. Kostova E, et al. Mol Hum Reprod, 2002 Aug. PMID 12149400
  4. A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males. Yen PH. Genomics, 1998 Nov 15. PMID 9806824
  5. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. Lahn BT, et al. Nat Genet, 1999 Apr. PMID 10192397

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Clone Names

  • MGC163298, MGC163300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H2AK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AK9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BK12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BK5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K122 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K14 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K18 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K23 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K27 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K56 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K8 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
testis-specific chromodomain protein Y 2
Names
Y chromosome chromodomain protein 2B
chromodomain protein, Y chromosome, 2 related
chromodomain protein, Y-linked, 2B
testis-specific chromodomain protein Y protein 2 related
NP_001001722.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001722.2 → NP_001001722.1  testis-specific chromodomain protein Y 2

    See identical proteins and their annotated locations for NP_001001722.1

    Status: REVIEWED

    Source sequence(s)
    AC009976, BC069087
    Consensus CDS
    CCDS35473.1
    UniProtKB/Swiss-Prot
    A8K868, Q9Y6F7
    UniProtKB/TrEMBL
    A1L473
    Related
    ENSP00000372319.3, ENST00000382867.4
    Conserved Domains (2) summary
    cd06558
    Location:287 → 483
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:5 → 58
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    17878260..17880220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    18784818..18786778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6F7.1 GenPept UniProtKB/Swiss-Prot:Q9Y6F7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools