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Selenop selenoprotein P [ Mus musculus (house mouse) ]

Gene ID: 20363, updated on 9-Dec-2024

Summary

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Official Symbol
Selenopprovided by MGI
Official Full Name
selenoprotein Pprovided by MGI
Primary source
MGI:MGI:894288
See related
Ensembl:ENSMUSG00000064373 AllianceGenome:MGI:894288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Se-P; selp; Sepp1; D15Ucla1
Summary
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in mouse), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants differing in 5' non-coding region have been described for this gene. Expression of these variants varies in different tissues and developmental stages (PMID:23064117). [provided by RefSeq, Feb 2017]
Expression
Broad expression in liver E18 (RPKM 1163.6), liver adult (RPKM 814.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Selenop in Genome Data Viewer
Location:
15 A1; 15 1.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (3300249..3309992)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (3270767..3280510)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37812 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37813 Neighboring gene predicted gene, 30057 Neighboring gene coiled-coil domain containing 152 Neighboring gene predicted gene, 41254 Neighboring gene growth hormone receptor Neighboring gene Ghr downstream L1 promoter region Neighboring gene Ghr upstream L2 promoter region Neighboring gene predicted gene, 22031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. All regions of mouse brain are dependent on selenoprotein P for maintenance of selenium. Nakayama A, et al. J Nutr, 2007 Mar. PMID 17311961
  2. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, et al. J Clin Invest, 2015 Jul 1. PMID 26053663, Free PMC Article
  3. Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Ishikura K, et al. Diabetologia, 2014 Sep. PMID 24989996
  4. Selenoprotein P is the essential selenium transporter for bones. Pietschmann N, et al. Metallomics, 2014 May. PMID 24626785
  5. Localization and regulation of pancreatic selenoprotein P. Steinbrenner H, et al. J Mol Endocrinol, 2013 Feb. PMID 23125459

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet.
    Title: Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet.
  2. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
    Title: SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
  3. Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
    Title: Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases.
  4. Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
    Title: Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat.
  5. Role of selenoprotein P expression in the function of pancreatic beta cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
    Title: Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
  6. Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
    Title: Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
  7. Selenoprotein P promotes the development of pulmonary hypertension by stimulating excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells.
    Title: Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
  8. In this study, the role of SeP in ischemia/reperfusion (I/R) injury has been investigated.
    Title: Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice.
  9. Results indicate a diversity of RNA elements conducting multiple occurrences of UGA redefinition to control the synthesis of full-length and truncated selenoprotein P (SELENOP) isoforms.
    Title: Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.
  10. Study suggests the 3' UTR structural elements (SECIS) in Sepp1 functions with site specificity and further illustrates how mRNA processing may produce transcripts with altered coding potential to produce diversity in selenoprotein isoforms.
    Title: Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables selenium binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in selenium compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within selenium compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within selenium compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
selenoprotein P
Names
plasma selenoprotein P
seP
selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042613.2 → NP_001036078.1  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_001036078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues. Variant Sepp1b is specifically localized to the hippocampus in the brain, and is a specific target for regulation by miR-7 microRNA (PMID:23064117).
    Source sequence(s)
    AA153204, AK002450, CK627189
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
    Related
    ENSMUSP00000081004.6, ENSMUST00000082424.12
    Conserved Domains (2) summary
    pfam04592
    Location:23 → 241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256 → 380
    SelP_C; Selenoprotein P, C terminal region

  2. NM_001042614.2 → NP_001036079.1  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_001036079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Sepp1c) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
    Source sequence(s)
    AA153204, AI892015, AK002450
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
    Conserved Domains (2) summary
    pfam04592
    Location:23 → 241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256 → 380
    SelP_C; Selenoprotein P, C terminal region

  3. NM_009155.4 → NP_033181.3  selenoprotein P precursor

    See identical proteins and their annotated locations for NP_033181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein containing 10 selenocysteine residues.
    Source sequence(s)
    AA153204, AK002450, CB231357
    Consensus CDS
    CCDS27357.1
    UniProtKB/Swiss-Prot
    P70274, Q3TJ31, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
    Related
    ENSMUSP00000124305.3, ENSMUST00000159216.10
    Conserved Domains (2) summary
    pfam04592
    Location:23 → 241
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:256 → 380
    SelP_C; Selenoprotein P, C terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    3300249..3309992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70274.3 GenPept UniProtKB/Swiss-Prot:P70274

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