Sorbs3 sorbin and SH3 domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sorbs3provided by MGI
Official Full Name: sorbin and SH3 domain containing 3provided by MGI
Primary source: MGI:MGI:700013
See related: Ensembl:ENSMUSG00000022091 AllianceGenome:MGI:700013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SH3P3; Sh3d4; SCAM-1; vinexin-g
Summary: Predicted to enable vinculin binding activity. Acts upstream of or within cell-substrate adhesion; negative regulation of transcription by RNA polymerase II; and positive regulation of MAPK cascade. Located in cytoplasm; focal adhesion; and nucleus. Is expressed in several structures, including eye; gonad; heart; hindbrain; and long bone epiphysis. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 40.0), adrenal adult (RPKM 39.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.27 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70417917..70449472, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70180468..70212023, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling.
Title: Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling.
Vinexin contributes to autophagic decline in brain ageing across species.
Title: Vinexin contributes to autophagic decline in brain ageing across species.
Vinexin beta deficiency exacerbates diet-induced obesity, hepatosteatosis, insulin resistance and endoplasmic reticulum stress in mice.
Title: Vinexin β deficiency exacerbates diet-induced obesity, hepatosteatosis, insulin resistance and endoplasmic reticulum stress in mice.
these results demonstrate that the H2 helix in vinexin alpha plays a critical role in ECM stiffness-dependent regulation of vinculin and cell behaviors.
Title: An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin.
These observations reveal a critical role of vinexin alpha and CAP in mechanotransduction and MSC differentiation.
Title: Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells.
Differential roles of SORBS proteins in mechanotransduction.
Title: Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.
Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis.
Title: Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis.
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha.
Title: The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix.
Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury
Title: Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis.
Vinexin-beta increases myocardial infarction-induced mortality and worsens cardiac dysfunction through aggravation of myocardial apoptosis and inflammatory response.
Title: Vinexin-β exacerbates cardiac dysfunction post-myocardial infarction via mediating apoptotic and inflammatory responses.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables vinculin binding	IEA Inferred from Electronic Annotation more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-substrate adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-substrate junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vinexin

Names: SH3 domain protein 4; SH3 domain-containing protein SH3P3; SH3-containing adapter molecule 1; vinexin alpha; vinexin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271407.2 → NP_001258336.1 vinexin isoform b

See identical proteins and their annotated locations for NP_001258336.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared at isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC151836

Consensus CDS

CCDS88702.1

UniProtKB/TrEMBL

A0A2I3BS41, Q8K0M3

Related

ENSMUSP00000154195.2, ENSMUST00000227653.2

Conserved Domains (5) summary

smart00459
Location:112 → 161

Sorb; Sorbin homologous domain

PTZ00449
Location:253 → 392

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:623 → 680

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:394 → 448

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:468 → 523

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
NM_001271408.1 → NP_001258337.1 vinexin isoform b

See identical proteins and their annotated locations for NP_001258337.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 3 encode the same isoform (b).

Source sequence(s)

AC151836

Consensus CDS

CCDS88702.1

UniProtKB/TrEMBL

A0A2I3BS41, Q8K0M3

Related

ENSMUSP00000153715.2, ENSMUST00000227259.2

Conserved Domains (5) summary

smart00459
Location:112 → 161

Sorb; Sorbin homologous domain

PTZ00449
Location:253 → 392

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:623 → 680

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:394 → 448

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:468 → 523

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
NM_001271409.2 → NP_001258338.1 vinexin isoform c

See identical proteins and their annotated locations for NP_001258338.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks multiple exons in the coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AC151836

Conserved Domains (3) summary

cd11918
Location:271 → 328

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:42 → 96

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:116 → 171

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
NM_001424655.1 → NP_001411584.1 vinexin isoform d

Status: VALIDATED

Source sequence(s)

AC151836

UniProtKB/TrEMBL

A0A2I3BS41
NM_011366.4 → NP_035496.1 vinexin isoform a

See identical proteins and their annotated locations for NP_035496.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC151836

Consensus CDS

CCDS27249.1

UniProtKB/Swiss-Prot

Q62423, Q9R1Z8

UniProtKB/TrEMBL

A0A2I3BS41

Related

ENSMUSP00000022682.6, ENSMUST00000022682.6

Conserved Domains (5) summary

smart00459
Location:165 → 214

Sorb; Sorbin homologous domain

PTZ00449
Location:306 → 445

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:676 → 733

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:447 → 501

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:521 → 576

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

RNA

NR_188830.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC151836
NR_188831.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC151836

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70417917..70449472 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518736.4 → XP_006518799.1 vinexin isoform X1

UniProtKB/TrEMBL

A0A2I3BS41

Related

ENSMUSP00000154773.2, ENSMUST00000227929.2

Conserved Domains (5) summary

smart00459
Location:150 → 199

Sorb; Sorbin homologous domain

PTZ00449
Location:291 → 430

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:661 → 718

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:432 → 486

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:506 → 561

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
XM_006518737.4 → XP_006518800.1 vinexin isoform X2

See identical proteins and their annotated locations for XP_006518800.1

UniProtKB/TrEMBL

A0A2I3BS41, Q8K0M3

Conserved Domains (5) summary

smart00459
Location:112 → 161

Sorb; Sorbin homologous domain

PTZ00449
Location:253 → 392

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:623 → 680

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:394 → 448

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:468 → 523

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
XM_006518741.2 → XP_006518804.1 vinexin isoform X5

See identical proteins and their annotated locations for XP_006518804.1

Conserved Domains (5) summary

PTZ00449
Location:163 → 302

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11918
Location:533 → 590

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:304 → 358

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:378 → 433

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cl02617
Location:40 → 71

Sorb; Sorbin homologous domain
XM_006518743.3 → XP_006518806.1 vinexin isoform X7

See identical proteins and their annotated locations for XP_006518806.1

Conserved Domains (3) summary

cd11918
Location:271 → 328

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:42 → 96

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:116 → 171

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)
XM_006518742.4 → XP_006518805.1 vinexin isoform X6

Conserved Domains (3) summary

cd11918
Location:325 → 382

SH3_Vinexin_3; Third (or C-terminal) Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11921
Location:96 → 150

SH3_Vinexin_1; First Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)

cd11924
Location:170 → 225

SH3_Vinexin_2; Second Src Homology 3 domain of Vinexin, also called Sorbin and SH3 domain containing 3 (Sorbs3)