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Sipa1 signal-induced proliferation associated gene 1 [ Mus musculus (house mouse) ]

Gene ID: 20469, updated on 9-Dec-2024

Summary

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Official Symbol
Sipa1provided by MGI
Official Full Name
signal-induced proliferation associated gene 1provided by MGI
Primary source
MGI:MGI:107576
See related
Ensembl:ENSMUSG00000056917 AllianceGenome:MGI:107576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spa1
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including endomembrane system; nucleus; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in several structures, including genitourinary system; heart; immune system; liver; and lung. Used to study chronic myeloid leukemia. Orthologous to human SIPA1 (signal-induced proliferation-associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in spleen adult (RPKM 156.5), thymus adult (RPKM 70.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Sipa1 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5701211..5713758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5651185..5663722, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian) Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Ishida D, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12958214, Free PMC Article
  2. Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. Xiao P, et al. Blood Adv, 2018 Mar 13. PMID 29514790, Free PMC Article
  3. Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells. Xu Y, et al. Nat Commun, 2018 Mar 2. PMID 29500416, Free PMC Article
  4. Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Ishida D, et al. Immunity, 2006 Apr. PMID 16618600
  5. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Ishida D, et al. Cancer Cell, 2003 Jul. PMID 12892713

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sipa1 loss-induced BM niche alterations likely enable evolution of clonal hematopoiesis to the hematological malignancies.
    Title: Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.
  2. Sipa1 deficiency uncovers a host immune mechanism potentially capable of eradicating Bcr-Abl(+) hematopoietic progenitor cells.
    Title: Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.
  3. afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
    Title: Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.
  4. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.
    Title: Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
  5. Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.
    Title: Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4074

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to water deprivation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal-induced proliferation-associated protein 1
Names
GTPase-activating protein Spa-1
sipa-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164480.2 → NP_001157952.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157952.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000128208.2, ENSMUST00000164304.9
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP

  2. NM_001164481.2 → NP_001157953.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157953.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000073618.6, ENSMUST00000071857.13
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP

  3. NM_001164482.2 → NP_001157954.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001157954.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000157692.2, ENSMUST00000237874.2
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP

  4. NM_001164568.2 → NP_001158040.1  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_001158040.1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000132345.2, ENSMUST00000169854.2
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP

  5. NM_001403064.1 → NP_001389993.1  signal-induced proliferation-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58

  6. NM_001403065.1 → NP_001389994.1  signal-induced proliferation-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    AC134563
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58

  7. NM_011379.5 → NP_035509.4  signal-induced proliferation-associated protein 1

    See identical proteins and their annotated locations for NP_035509.4

    Status: VALIDATED

    Source sequence(s)
    AC134563
    Consensus CDS
    CCDS29474.1
    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Related
    ENSMUSP00000079637.6, ENSMUST00000080824.13
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5701211..5713758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161493.1 → XP_036017386.1  signal-induced proliferation-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    E9Q0Y4, Q3UE96, Q3UV58
    Conserved Domains (4) summary
    PHA03378
    Location:29 → 112
    PHA03378; EBNA-3B; Provisional
    COG1196
    Location:901 → 1023
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00595
    Location:683 → 755
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam02145
    Location:347 → 528
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46062.2 GenPept UniProtKB/Swiss-Prot:P46062

Gene LinkOut

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