Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc1a1provided by MGI
Official Full Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1provided by MGI
Primary source: MGI:MGI:105083
See related: Ensembl:ENSMUSG00000024935 AllianceGenome:MGI:105083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik
Summary: Enables anion transmembrane transporter activity and identical protein binding activity. Involved in several processes, including cation transmembrane transport; learning or memory; and response to alkaloid. Acts upstream of or within several processes, including behavioral fear response; ion homeostasis; and regulation of cellular protein metabolic process. Located in several cellular components, including apical plasma membrane; endosome membrane; and membrane raft. Is integral component of plasma membrane. Is active in cytoplasm and dendrite. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 43.4), kidney adult (RPKM 33.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 23.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (28812535..28891360)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (28835135..28913960)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EAAT3 impedes oligodendrocyte remyelination in chronic cerebral hypoperfusion-induced white matter injury.
Title: EAAT3 impedes oligodendrocyte remyelination in chronic cerebral hypoperfusion-induced white matter injury.
HIF-1alpha drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1.
Title: HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1.
SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors.
Title: SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors.
Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy.
Title: Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy.
Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.
Title: Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior.
The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn(2+) accumulation.
Title: The role of diurnal fluctuations in excitatory amino acid carrier 1 levels in post-ischemic hippocampal Zn(2+) accumulation.
Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice.
Title: Neuregulin-1 inhibits CoCl(2)-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice.
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc(-) for Glutathione Synthesis in Lung Cancer.
Title: Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc(-) for Glutathione Synthesis in Lung Cancer.
EAAC1 is important for the survival of newly generated neurons in the adult brain under physiological and pathological conditions. Therefore, this study suggests that EAAC1 plays an essential role in modulating hippocampal neurogenesis.
Title: EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia.
This study found high EAAT3 protein levels in the brush borders of both the distal small intestine and the renal proximal tubules.
Title: Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc1a1 (e-PCR), detects polymorphism
- UniSTS:144415

U73521 (e-PCR)
- UniSTS:160820

Slc1a1 (e-PCR), detects polymorphism
- UniSTS:545988

STS-Z40795 (e-PCR)
- UniSTS:81605

Slc1a1 (e-PCR), detects polymorphism
- UniSTS:547013

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cysteine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase B activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amino acid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to ammonium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to ammonium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to bisphenol A	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cocaine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to mercury ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cysteine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine transport	ISO Inferred from Sequence Orthology more info
involved_in cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular glutamate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter receptor transport to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anesthetic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to axon injury	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to decreased oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to decreased oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to morphine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to morphine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in distal dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perisynaptic space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in proximal dendrite	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: excitatory amino acid transporter 3

Names: excitatory amino acid carrier 2; excitatory amino-acid carrier 1; glutamate transporter mEAAC2; sodium-dependent glutamate/aspartate transporter 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.