U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 [ Mus musculus (house mouse) ]

Gene ID: 20521, updated on 9-Dec-2024

Summary

Official Symbol
Slc22a12provided by MGI
Official Full Name
solute carrier family 22 (organic anion/cation transporter), member 12provided by MGI
Primary source
MGI:MGI:1195269
See related
Ensembl:ENSMUSG00000061742 AllianceGenome:MGI:1195269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rst; OAT4L; URAT1; Slc22al2
Summary
Enables urate transmembrane transporter activity. Involved in urate transport. Located in brush border membrane. Is expressed in central nervous system; dorsal root ganglion; male reproductive gland or organ; metanephros; and retina layer. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward kidney adult (RPKM 561.9) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Slc22a12 in Genome Data Viewer
Location:
19 A; 19 5.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6585884..6593100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6535854..6543070, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene STARR-seq mESC enhancer starr_45434 Neighboring gene STARR-positive B cell enhancer ABC_E8733 Neighboring gene predicted gene 14965 Neighboring gene neurexin II Neighboring gene STARR-seq mESC enhancer starr_45436 Neighboring gene STARR-positive B cell enhancer ABC_E5683 Neighboring gene predicted gene, 52381 Neighboring gene predicted gene, 32245 Neighboring gene high mobility group box 1, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Markers

Potential readthrough

Included gene: Nrxn2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables urate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within urate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in urate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
solute carrier family 22 member 12
Names
renal-specific transporter
solute carrier family 22 (organic cation transporter)-like 2
urate anion exchanger 1
urate:anion antiporter SLC22A12

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009203.3NP_033229.3  solute carrier family 22 member 12

    See identical proteins and their annotated locations for NP_033229.3

    Status: VALIDATED

    Source sequence(s)
    AB005451, AI314749, AK142580, BX631781, CD241755
    Consensus CDS
    CCDS29505.1
    UniProtKB/Swiss-Prot
    O54778, Q8CFZ5
    UniProtKB/TrEMBL
    A0A0R4J1I9
    Related
    ENSMUSP00000109078.2, ENSMUST00000113451.9
    Conserved Domains (2) summary
    cd06174
    Location:147516
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11526
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6585884..6593100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)