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Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin [ Mus musculus (house mouse) ]

Gene ID: 20612, updated on 9-Dec-2024

Summary

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Official Symbol
Siglec1provided by MGI
Official Full Name
sialic acid binding Ig-like lectin 1, sialoadhesinprovided by MGI
Primary source
MGI:MGI:99668
See related
Ensembl:ENSMUSG00000027322 AllianceGenome:MGI:99668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sn; Cd169; Siglec-1
Summary
Predicted to enable virion binding activity. Acts upstream of or within positive regulation of T cell apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular region. Predicted to be active in early endosome; late endosome; and plasma membrane. Is expressed in immune system; reproductive system; and skin. Orthologous to human SIGLEC1 (sialic acid binding Ig like lectin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in mammary gland adult (RPKM 31.7), spleen adult (RPKM 18.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Siglec1 in Genome Data Viewer
Location:
2 F1; 2 63.26 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130911140..130928697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131067801..131086778, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 6973b Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 4 Neighboring gene a disintegrin and metallopeptidase domain 33 Neighboring gene STARR-seq mESC enhancer starr_05699 Neighboring gene predicted gene, 30378 Neighboring gene heat shock protein 12B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169). Bradford BM, et al. Immunology, 2014 Sep. PMID 24684244, Free PMC Article
  2. Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis. Singh R, et al. Elife, 2019 Dec 24. PMID 31872800, Free PMC Article
  3. Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1. Perez-Zsolt D, et al. Front Immunol, 2019. PMID 31114569, Free PMC Article
  4. Targeted Delivery of Antigen to Activated CD169(+) Macrophages Induces Bias for Expansion of CD8(+) T Cells. Edgar LJ, et al. Cell Chem Biol, 2019 Jan 17. PMID 30393066, Free PMC Article
  5. Transient Depletion of CD169(+) Cells Contributes to Impaired Early Protection and Effector CD8(+) T Cell Recruitment against Mucosal Respiratory Syncytial Virus Infection. Oh DS, et al. Front Immunol, 2017. PMID 28751894, Free PMC Article

See all (147) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
    Title: CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
  2. CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.
    Title: CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.
  3. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
    Title: Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.
  4. Campylobacter jejuni induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes.
    Title: Campylobacter jejuni induces autoimmune peripheral neuropathy via Sialoadhesin and Interleukin-4 axes.
  5. Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
    Title: Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
  6. Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.
    Title: Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1.
  7. the interaction between Siglec1-expressing SCS macrophages and pioneer metastatic cells drives cell cycle progression and enables efficient metastatic colonization
    Title: Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis.
  8. An IL-4R-dependent increase of CD169 was observed on pleural and bronchoalveolar macrophages in microfilaremic mice.
    Title: IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.
  9. the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis
    Title: Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.
  10. A new subset of resident macrophages in the intestinal muscularis externa was discovered, identified as iba1(pos) CD169(neg).
    Title: Ionized calcium-binding adaptor molecule 1 positive macrophages and HO-1 up-regulation in intestinal muscularis resident macrophages.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis of virus by host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sialoadhesin
Names
SER
sheep erythrocyte receptor
sialic acid-binding Ig-like lectin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011426.3 → NP_035556.3  sialoadhesin precursor

    See identical proteins and their annotated locations for NP_035556.3

    Status: VALIDATED

    Source sequence(s)
    AA396073, BC141335, Z36293
    Consensus CDS
    CCDS16754.2
    UniProtKB/Swiss-Prot
    D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
    UniProtKB/TrEMBL
    G3X8X6
    Related
    ENSMUSP00000028794.4, ENSMUST00000028794.10
    Conserved Domains (9) summary
    cd05712
    Location:27 → 136
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:261 → 319
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:343 → 415
    IG; Immunoglobulin
    smart00410
    Location:624 → 702
    IG_like; Immunoglobulin like
    cd00096
    Location:1365 → 1440
    Ig; Immunoglobulin domain
    pfam08205
    Location:148 → 235
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:1269 → 1340
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:1090 → 1151
    Ig_3; Immunoglobulin domain
    cl11960
    Location:428 → 511
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    130911140..130928697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499050.5 → XP_006499113.1  sialoadhesin isoform X3

    UniProtKB/Swiss-Prot
    D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
    Conserved Domains (9) summary
    cd05712
    Location:27 → 136
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:261 → 319
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:624 → 702
    IG; Immunoglobulin
    smart00410
    Location:343 → 415
    IG_like; Immunoglobulin like
    cd00096
    Location:1365 → 1440
    Ig; Immunoglobulin domain
    pfam08205
    Location:148 → 235
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:1269 → 1340
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:1090 → 1151
    Ig_3; Immunoglobulin domain
    cl11960
    Location:428 → 511
    Ig; Immunoglobulin domain

  2. XM_036159918.1 → XP_036015811.1  sialoadhesin isoform X2

    UniProtKB/Swiss-Prot
    D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
    Conserved Domains (9) summary
    smart00408
    Location:261 → 319
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:624 → 702
    IG; Immunoglobulin
    smart00410
    Location:1005 → 1093
    IG_like; Immunoglobulin like
    pfam08205
    Location:148 → 235
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:1095 → 1167
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:712 → 777
    Ig_3; Immunoglobulin domain
    cd00096
    Location:148 → 153
    Ig; Ig strand A [structural motif]
    cd05712
    Location:27 → 134
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cl11960
    Location:428 → 511
    Ig; Immunoglobulin domain

  3. XM_036159916.1 → XP_036015809.1  sialoadhesin isoform X1

    UniProtKB/Swiss-Prot
    D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
    Conserved Domains (9) summary
    smart00408
    Location:261 → 319
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:624 → 702
    IG; Immunoglobulin
    smart00410
    Location:1005 → 1093
    IG_like; Immunoglobulin like
    pfam08205
    Location:148 → 235
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:1095 → 1167
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:712 → 777
    Ig_3; Immunoglobulin domain
    cd00096
    Location:148 → 153
    Ig; Ig strand A [structural motif]
    cd05712
    Location:27 → 134
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cl11960
    Location:428 → 511
    Ig; Immunoglobulin domain

  4. XM_006499051.5 → XP_006499114.1  sialoadhesin isoform X4

    UniProtKB/Swiss-Prot
    D3YVZ3, D3YVZ4, O55216, Q62228, Q62229, Q62230
    Related
    ENSMUSP00000105856.2, ENSMUST00000110227.8
    Conserved Domains (9) summary
    cd05712
    Location:27 → 136
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00408
    Location:261 → 319
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:624 → 702
    IG; Immunoglobulin
    smart00410
    Location:343 → 415
    IG_like; Immunoglobulin like
    cd00096
    Location:1365 → 1440
    Ig; Immunoglobulin domain
    pfam08205
    Location:148 → 235
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:1269 → 1340
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:1090 → 1151
    Ig_3; Immunoglobulin domain
    cl11960
    Location:428 → 511
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62230.2 GenPept UniProtKB/Swiss-Prot:Q62230

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