Sprr3 small proline-rich protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprr3provided by MGI
Official Full Name: small proline-rich protein 3provided by MGI
Primary source: MGI:MGI:1330237
See related: Ensembl:ENSMUSG00000045539 AllianceGenome:MGI:1330237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPR3
Summary: Predicted to be involved in keratinization. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human SPRR3 (small proline rich protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward stomach adult (RPKM 766.4) See more
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92363809..92366027, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92456502..92458720, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPRR3 protects an atheroma lesion from vascular smooth muscle cell (VSMC) loss by promoting survival signaling in plaque VSMCs, thereby significantly decreasing atherosclerosis progression.
Title: Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.
These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment.
Title: Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
Esophagin/SPRR3 may play a role in the maintenance of normal esophageal epithelial homeostasis, and aberrant expression of Esophagin/SPRR3 may contribute to the tumorigenesis of esophageal squamous cell carcinoma
Title: Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491365

16.MMHAP28FLF1.seq (e-PCR)
- UniSTS:123301

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in keratinization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small proline-rich protein 3

Names: cornifin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204427.1 → NP_001191356.1 small proline-rich protein 3

See identical proteins and their annotated locations for NP_001191356.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC127036

Consensus CDS

CCDS17558.1

UniProtKB/Swiss-Prot

O09116, Q059J8

Conserved Domains (1) summary

pfam02389
Location:17 → 149

Cornifin; Cornifin (SPRR) family
NM_011478.2 → NP_035608.1 small proline-rich protein 3

See identical proteins and their annotated locations for NP_035608.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC125629, BY709657, EH099911

Consensus CDS

CCDS17558.1

UniProtKB/Swiss-Prot

O09116, Q059J8

Related

ENSMUSP00000056287.4, ENSMUST00000058142.4

Conserved Domains (1) summary

pfam02389
Location:17 → 149

Cornifin; Cornifin (SPRR) family