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Stra8 stimulated by retinoic acid gene 8 [ Mus musculus (house mouse) ]

Gene ID: 20899, updated on 9-Dec-2024

Summary

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Official Symbol
Stra8provided by MGI
Official Full Name
stimulated by retinoic acid gene 8provided by MGI
Primary source
MGI:MGI:107917
See related
Ensembl:ENSMUSG00000029848 AllianceGenome:MGI:107917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in several processes, including activation of meiosis; cellular response to retinoic acid; and germ cell development. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including 2-cell stage embryo; ganglia; gonad; mesonephros; and spleen primordium. Orthologous to human STRA8 (stimulated by retinoic acid 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis adult (RPKM 2.9) See more
Orthologs
human all
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Genomic context

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See Stra8 in Genome Data Viewer
Location:
6 B1; 6 15.2 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34897098..34916279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34920163..34939344)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene WD repeat domain 91 Neighboring gene STARR-positive B cell enhancer mm9_chr6:34860831-34861132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34902551-34902660 Neighboring gene solute carrier family 23 member 4 Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene STARR-seq mESC enhancer starr_15552 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells. Ishihara T, et al. Reproduction, 2023 May 1. PMID 36866926
  2. Expression profile of a 400-bp Stra8 promoter region during spermatogenesis. Antonangeli F, et al. Microsc Res Tech, 2009 Nov. PMID 19378319
  3. STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. Mark M, et al. J Cell Sci, 2008 Oct 1. PMID 18799790
  4. Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Zhou Q, et al. Biol Reprod, 2008 Jul. PMID 18322276, Free PMC Article
  5. Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells. Zhang X, et al. Cell Rep, 2023 Jul 25. PMID 37405912, Free PMC Article

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
    Title: STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.
  2. Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells.
    Title: Conserved H3K27me3-associated chromatin remodelling allows STRA8 but not MEIOSIN expression in mammalian germ cells.
  3. Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
    Title: Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
  4. The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.
    Title: The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis.
  5. Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mousedagger.
    Title: Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse†.
  6. STRA8 induces transcriptional changes in germ cells during spermatogonial development.
    Title: STRA8 induces transcriptional changes in germ cells during spermatogonial development.
  7. Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse.
    Title: Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse.
  8. Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
    Title: Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
  9. Here, the authors examined cells undergoing meiotic initiation in mice, and found that initiation involves the dramatic upregulation of a transcriptional network of thousands of genes whose expression is not limited to meiosis. This broad gene expression program is directly upregulated by STRA8, encoded by a germ cell-specific gene required for meiotic initiation.
    Title: Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice.
  10. Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
    Title: Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
stimulated by retinoic acid gene 8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410379.1 → NP_001397308.1  stimulated by retinoic acid gene 8 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153869

  2. NM_001410380.1 → NP_001397309.1  stimulated by retinoic acid gene 8 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153869
    UniProtKB/TrEMBL
    F2Z435
    Related
    ENSMUSP00000110649.2, ENSMUST00000114997.3

  3. NM_009292.3 → NP_033318.1  stimulated by retinoic acid gene 8 protein isoform 1

    See identical proteins and their annotated locations for NP_033318.1

    Status: VALIDATED

    Source sequence(s)
    AC153869
    Consensus CDS
    CCDS39458.1
    UniProtKB/Swiss-Prot
    P70278, Q496Q5
    Related
    ENSMUSP00000110651.2, ENSMUST00000114999.8
    Conserved Domains (1) summary
    cl00081
    Location:30 → 90
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34897098..34916279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241270.1 → XP_011239572.1  stimulated by retinoic acid gene 8 protein isoform X1

    See identical proteins and their annotated locations for XP_011239572.1

    UniProtKB/Swiss-Prot
    P70278, Q496Q5
    Related
    ENSMUSP00000031876.5, ENSMUST00000031876.12
    Conserved Domains (1) summary
    cl00081
    Location:30 → 90
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70278.1 GenPept UniProtKB/Swiss-Prot:P70278

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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