U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 20916, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Sucla2provided by MGI
Official Full Name
succinate-Coenzyme A ligase, ADP-forming, beta subunitprovided by MGI
Primary source
MGI:MGI:1306775
See related
Ensembl:ENSMUSG00000022110 AllianceGenome:MGI:1306775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A-SCS; SCS-betaA; 4930547K18Rik
Summary
Predicted to enable succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Part of succinate-CoA ligase complex (ADP-forming). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study mitochondrial DNA depletion syndrome 5. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in heart adult (RPKM 50.4), testis adult (RPKM 42.5) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sucla2 in Genome Data Viewer
Location:
14 D3; 14 39.06 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73790226..73833584)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73552786..73596144)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7336 Neighboring gene STARR-positive B cell enhancer ABC_E936 Neighboring gene STARR-positive B cell enhancer ABC_E9408 Neighboring gene STARR-seq mESC enhancer starr_37120 Neighboring gene mediator complex subunit 4 Neighboring gene nudix hydrolase 15 Neighboring gene predicted gene, 41209 Neighboring gene STARR-positive B cell enhancer ABC_E3125 Neighboring gene STARR-seq mESC enhancer starr_37122 Neighboring gene predicted gene, 24540 Neighboring gene ribosomal protein S6 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism. Lancaster MS, et al. Cell Rep, 2023 Oct 31. PMID 37819759, Free PMC Article
  2. Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Donti TR, et al. Dis Model Mech, 2014 Feb. PMID 24271779, Free PMC Article
  3. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Zhao Y, et al. Sci Rep, 2017 Aug 2. PMID 28769029, Free PMC Article
  4. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, et al. Biochem J, 2016 Oct 15. PMID 27496549, Free PMC Article
  5. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Tong Y, et al. Mol Cell, 2021 Jun 3. PMID 33991485

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
    Title: SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
  2. SCS A-beta loss mediates severe mitochondrial dysfunction including compromised OXPHOS efficiency, increased ROS generation, mtDNA depletion as well as altered mitochondrial dynamics towards fusion.
    Title: Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons.
  3. Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion.
    Title: Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.
  4. ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity
    Title: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity ISO
Inferred from Sequence Orthology
more info
  
enables succinate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in succinate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in succinyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
part_of succinate-CoA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Names
ATP-specific succinyl-CoA synthetase subunit beta
succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
succinyl-CoA synthetase beta-A chain
NP_001348567.1
NP_035636.1
XP_006518820.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361638.1 → NP_001348567.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Conserved Domains (1) summary
    cl25712
    Location:1 → 311
    SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]

  2. NM_011506.4 → NP_035636.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_035636.1

    Status: VALIDATED

    Source sequence(s)
    AC113198, AC155246
    Consensus CDS
    CCDS27271.1
    UniProtKB/Swiss-Prot
    Q3TVH1, Q8BGS6, Q9Z2I9
    UniProtKB/TrEMBL
    Q3UCC6
    Related
    ENSMUSP00000123765.2, ENSMUST00000160507.8
    Conserved Domains (3) summary
    PRK00696
    Location:55 → 445
    sucC; succinyl-CoA synthetase subunit beta; Provisional
    pfam00549
    Location:321 → 441
    Ligase_CoA; CoA-ligase
    pfam08442
    Location:55 → 262
    ATP-grasp_2; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    73790226..73833584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518757.4 → XP_006518820.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3UCC6
    Conserved Domains (1) summary
    PRK00696
    Location:92 → 482
    sucC; ADP-forming succinate--CoA ligase subunit beta
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2I9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2I9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous