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Swap70 SWA-70 protein [ Mus musculus (house mouse) ]

Gene ID: 20947, updated on 27-Aug-2024

Summary

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Official Symbol
Swap70provided by MGI
Official Full Name
SWA-70 proteinprovided by MGI
Primary source
MGI:MGI:1298390
See related
Ensembl:ENSMUSG00000031015 AllianceGenome:MGI:1298390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
70kDa
Summary
Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; negative regulation of peptidyl-serine dephosphorylation; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 24.4), lung adult (RPKM 11.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109820890..109882720)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110221703..110283506)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505 Neighboring gene STARR-positive B cell enhancer ABC_E8201 Neighboring gene STARR-positive B cell enhancer ABC_E704 Neighboring gene STARR-positive B cell enhancer ABC_E9296 Neighboring gene predicted gene, 32861 Neighboring gene 40S ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c(+) Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics. Ocaña-Morgner C, et al. J Immunol, 2017 Jun 1. PMID 28468968
  2. SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts. Chang YT, et al. Exp Cell Res, 2016 Jul 15. PMID 26103139
  3. SWAP-70: a new type of oncogene. Shu CL, et al. PLoS One, 2013. PMID 23555004, Free PMC Article
  4. Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70. Götz A, et al. PLoS One, 2013. PMID 23544157, Free PMC Article
  5. Regulation of bone mass and osteoclast function depend on the F-actin modulator SWAP-70. Garbe AI, et al. J Bone Miner Res, 2012 Oct. PMID 22648978

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The F-actin bundler SWAP-70 promotes tumor metastasis.
    Title: The F-actin bundler SWAP-70 promotes tumor metastasis.
  2. SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
    Title: SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
  3. Mechanism of control of F-actin cortex architecture by SWAP-70.
    Title: Mechanism of control of F-actin cortex architecture by SWAP-70.
  4. Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
    Title: Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
  5. Data support an essential and specific role for SWAP70 in tethering and stabilizing F-actin to the phagosomal surface in a wide range of phagocytes.
    Title: SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes.
  6. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
    Title: Regulation of systemic autoimmunity and CD11c(+) Tbet(+) B cells by SWEF proteins.
  7. findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides
    Title: Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c(+) Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics.
  8. DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
    Title: SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
  9. SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts.
    Title: SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts.
  10. These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
    Title: The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within isotype switching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell-cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidyl-serine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mast cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somatic cell DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
switch-associated protein 70
Names
SWAP complex protein, 70 kDa
SWAP-70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417315.1 → NP_001404244.1  switch-associated protein 70 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124472, AC147244

  2. NM_009302.4 → NP_033328.3  switch-associated protein 70 isoform 1

    See identical proteins and their annotated locations for NP_033328.3

    Status: VALIDATED

    Source sequence(s)
    AC124472, AC147244
    Consensus CDS
    CCDS21744.1
    UniProtKB/Swiss-Prot
    O88443, Q3TQR6, Q3UCA3, Q6A028, Q6P1D0
    Related
    ENSMUSP00000033325.8, ENSMUST00000033325.9
    Conserved Domains (4) summary
    cd13273
    Location:204 → 313
    PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
    pfam00169
    Location:211 → 306
    PH; PH domain
    pfam15665
    Location:316 → 527
    FAM184; Family with sequence similarity 184, A and B
    cl23849
    Location:321 → 455
    TrbI; Bacterial conjugation TrbI-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109820890..109882720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152861.1 → XP_036008754.1  switch-associated protein 70 isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:74 → 291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:5 → 55
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A028.2 GenPept UniProtKB/Swiss-Prot:Q6A028

Gene LinkOut

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