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Nemp1 nuclear envelope integral membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 210035, updated on 9-Dec-2024

Summary

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Official Symbol
Nemp1provided by MGI
Official Full Name
nuclear envelope integral membrane protein 1provided by MGI
Primary source
MGI:MGI:2446113
See related
Ensembl:ENSMUSG00000040195 AllianceGenome:MGI:2446113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem194; Tmem194a
Summary
Involved in erythrocyte enucleation. Located in nuclear envelope. Orthologous to human NEMP1 (nuclear envelope integral membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 9.0), liver E14 (RPKM 1.3) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Nemp1 in Genome Data Viewer
Location:
10 D3; 10 74.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127512934..127536918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127677065..127701049)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127105871-127106058 Neighboring gene STARR-positive B cell enhancer ABC_E2971 Neighboring gene STARR-positive B cell enhancer ABC_E1133 Neighboring gene predicted gene 16230 Neighboring gene STARR-positive B cell enhancer ABC_E5197 Neighboring gene myosin IA Neighboring gene tachykinin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts. Hodzic D, et al. PLoS Biol, 2022 Oct. PMID 36215313, Free PMC Article
  2. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Tsatskis Y, et al. Sci Adv, 2020 Aug. PMID 32923640, Free PMC Article
  3. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. Suzuki A, et al. J Reprod Immunol, 2024 Jun. PMID 38697008,
  4. The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes. Shibano T, et al. PLoS One, 2015. PMID 25946333, Free PMC Article
  5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.
    Title: The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.
  2. Nemp1 represents a new type of RanGTP-binding protein.
    Title: The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40914

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in erythrocyte enucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear membrane organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear envelope integral membrane protein 1
Names
transmembrane protein 194
transmembrane protein 194A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113211.1 → NP_001106682.1  nuclear envelope integral membrane protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001106682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC160970, AK129110
    Consensus CDS
    CCDS48720.1
    UniProtKB/Swiss-Prot
    Q6ZQE4
    UniProtKB/TrEMBL
    E9Q6Z3
    Related
    ENSMUSP00000045988.5, ENSMUST00000048099.5
    Conserved Domains (1) summary
    pfam10225
    Location:150 → 396
    NEMP; NEMP family

  2. NM_173732.3 → NP_776093.1  nuclear envelope integral membrane protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_776093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC160970, AK090031
    Consensus CDS
    CCDS48721.1
    UniProtKB/TrEMBL
    Q8K2N3
    Related
    ENSMUSP00000113337.2, ENSMUST00000118612.8
    Conserved Domains (1) summary
    pfam10225
    Location:150 → 321
    DUF2215; Uncharacterized conserved protein (DUF2215)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127512934..127536918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243393.2 → XP_011241695.1  nuclear envelope integral membrane protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10225
    Location:1 → 207
    NEMP; NEMP family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQE4.2 GenPept UniProtKB/Swiss-Prot:Q6ZQE4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
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