Adcy2 adenylate cyclase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy2provided by MGI
Official Full Name: adenylate cyclase 2provided by MGI
Primary source: MGI:MGI:99676
See related: Ensembl:ENSMUSG00000021536 AllianceGenome:MGI:99676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1060
Summary: Enables adenylate cyclase binding activity. Predicted to be involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and cAMP-mediated signaling. Predicted to act upstream of or within activation of adenylate cyclase activity. Located in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 27.4), cortex adult (RPKM 24.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 35.55 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (68768162..69147719, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (68620043..68999600, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
Title: MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2.
This study demonistrated that adcy2 knockout mice regulate the expression soluble adenylyl cyclase in brain.
Title: Neuronal expression of soluble adenylyl cyclase in the mammalian brain.
Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Markers

BB387438 (e-PCR)
- UniSTS:208952

MHAa74a1.seq (e-PCR)
- UniSTS:125301

D13Mit281 (e-PCR), detects polymorphism
- UniSTS:127100

ADCY2 (e-PCR)
- UniSTS:479881

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenylate cyclase binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate cyclase type 2

Names: ATP pyrophosphate-lyase 2; adenylate cyclase type II; adenylyl cyclase 2

NP_705762.2

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153534.2 → NP_705762.2 adenylate cyclase type 2

See identical proteins and their annotated locations for NP_705762.2

Status: VALIDATED

Source sequence(s)

AI322582, AK132312, BY623048

Consensus CDS

CCDS36721.1

UniProtKB/Swiss-Prot

Q80TL1, Q8CFU6

UniProtKB/TrEMBL

Q3V1Q3

Related

ENSMUSP00000022013.8, ENSMUST00000022013.8

Conserved Domains (4) summary

smart00044
Location:240 → 443

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:882 → 1081

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:499 → 603

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:37 → 264

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region