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Arhgef19 Rho guanine nucleotide exchange factor 19 [ Mus musculus (house mouse) ]

Gene ID: 213649, updated on 17-Aug-2024

Summary

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Official Symbol
Arhgef19provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 19provided by MGI
Primary source
MGI:MGI:1925912
See related
Ensembl:ENSMUSG00000028919 AllianceGenome:MGI:1925912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WGEF; 6030432F23; 6430573B13Rik
Summary
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within positive regulation of GTPase activity and wound healing. Is expressed in several structures, including genitourinary system; nose; oral epithelium; pharyngo-tympanic tube; and vibrissa. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 12.6), duodenum adult (RPKM 12.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 73.53 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140966916..140985226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141239605..141257915)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3534 Neighboring gene F-box protein 42 Neighboring gene STARR-seq mESC enhancer starr_11892 Neighboring gene STARR-positive B cell enhancer ABC_E10273 Neighboring gene STARR-positive B cell enhancer ABC_E3535 Neighboring gene STARR-positive B cell enhancer ABC_E6249 Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:140795314-140795615 Neighboring gene predicted gene, 52686 Neighboring gene STARR-seq mESC enhancer starr_11896 Neighboring gene STARR-seq mESC enhancer starr_11899 Neighboring gene predicted gene 13056 Neighboring gene STARR-seq mESC enhancer starr_11901 Neighboring gene Eph receptor A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF. Horii T, et al. PLoS One, 2009 Jun 5. PMID 19503838, Free PMC Article
  2. WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney. Wang Y, et al. Biochem Biophys Res Commun, 2004 Nov 19. PMID 15485661
  3. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Tsuji T, et al. Mol Biol Cell, 2010 Oct 15. PMID 20810787, Free PMC Article
  4. Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis. Kimura-Yoshida C, et al. Nat Commun, 2018 Oct 3. PMID 30283008, Free PMC Article
  5. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Caddy J, et al. Dev Cell, 2010 Jul 20. PMID 20643356, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. adipogenesis is regulated by WGEF expression through DNA methylation change
    Title: Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
  2. WGEF is a RhoGEF expressed in intestine, liver, heart, and kidney
    Title: WGEF is a novel RhoGEF expressed in intestine, liver, heart, and kidney.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 19
Names
Rho guanine nucleotide exchange factor (GEF) 19
ephexin-2
weakly similar to Rho GEF 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379647.1 → NP_001366576.1  rho guanine nucleotide exchange factor 19

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AL607087
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  2. NM_001379652.1 → NP_001366581.1  rho guanine nucleotide exchange factor 19

    Status: VALIDATED

    Source sequence(s)
    AL607087
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  3. NM_172520.3 → NP_766108.1  rho guanine nucleotide exchange factor 19

    See identical proteins and their annotated locations for NP_766108.1

    Status: VALIDATED

    Source sequence(s)
    AL607087
    Consensus CDS
    CCDS18868.1
    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Related
    ENSMUSP00000006618.3, ENSMUST00000006618.9
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140966916..140985226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250225.3 → XP_011248527.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_011248527.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  2. XM_006538705.2 → XP_006538768.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538768.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  3. XM_017320098.1 → XP_017175587.1  rho guanine nucleotide exchange factor 19 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  4. XM_006538709.5 → XP_006538772.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538772.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily

  5. XM_006538708.4 → XP_006538771.1  rho guanine nucleotide exchange factor 19 isoform X1

    See identical proteins and their annotated locations for XP_006538771.1

    UniProtKB/Swiss-Prot
    Q6PAC2, Q8BWA8
    Conserved Domains (3) summary
    cd01221
    Location:580 → 706
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:382 → 558
    RhoGEF; RhoGEF domain
    cl17036
    Location:719 → 773
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWA8.1 GenPept UniProtKB/Swiss-Prot:Q8BWA8

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