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Phactr2 phosphatase and actin regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 215789, updated on 28-Oct-2024

Summary

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Official Symbol
Phactr2provided by MGI
Official Full Name
phosphatase and actin regulator 2provided by MGI
Primary source
MGI:MGI:2446138
See related
Ensembl:ENSMUSG00000062866 AllianceGenome:MGI:2446138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in several structures, including body cavity or lining; brain; genitourinary system; respiratory system; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Parkinson's disease and multiple sclerosis. Orthologous to human PHACTR2 (phosphatase and actin regulator 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 5.6), limb E14.5 (RPKM 4.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Phactr2 in Genome Data Viewer
Location:
10 A2; 10 4.72 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (13083461..13350266, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13207717..13474525, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene predicted gene, 46211 Neighboring gene STARR-seq mESC enhancer starr_25813 Neighboring gene STARR-seq mESC enhancer starr_25814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13220839-13220948 Neighboring gene STARR-seq mESC enhancer starr_25815 Neighboring gene fucosidase, alpha-L- 2, plasma Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:13272745-13273072 Neighboring gene peroxisomal biogenesis factor 3 Neighboring gene adenosine deaminase, tRNA-specific 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Different expression patterns of Phactr family members in normal and injured mouse brain. Kim JY, et al. Neuroscience, 2012 Sep 27. PMID 22766235
  2. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15107502, Free PMC Article
  3. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Wilson CH, et al. EMBO J, 2012 May 30. PMID 22510880, Free PMC Article
  4. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that the mRNA expression of phactr2 was progressively increased in the injury penumbra.
    Title: Different expression patterns of Phactr family members in normal and injured mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033257.5 → NP_001028429.1  phosphatase and actin regulator 2 isoform D

    See identical proteins and their annotated locations for NP_001028429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon and lacks an in-frame exon, compared to variant A. The encoded isoform (D) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AK142930, AL713985, CJ060660
    Consensus CDS
    CCDS35846.1
    UniProtKB/TrEMBL
    A3KGD2, B1AVP0, Q3UQ19
    Related
    ENSMUSP00000101182.3, ENSMUST00000105543.9
    Conserved Domains (2) summary
    smart00707
    Location:445 → 469
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:72 → 94
    RPEL; RPEL repeat

  2. NM_001195065.1 → NP_001181994.1  phosphatase and actin regulator 2 isoform A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AC156949, AL713985
    Consensus CDS
    CCDS87962.1
    UniProtKB/TrEMBL
    F7D4H5, Q91VK6
    Related
    ENSMUSP00000101184.6, ENSMUST00000105545.12
    Conserved Domains (1) summary
    smart00707
    Location:508 → 532
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  3. NM_001195066.1 → NP_001181995.1  phosphatase and actin regulator 2 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AK139466, AL713985
    Consensus CDS
    CCDS87961.1
    UniProtKB/TrEMBL
    B1AVN9, B1AVP0
    Related
    ENSMUSP00000078637.7, ENSMUST00000079698.7
    Conserved Domains (2) summary
    smart00707
    Location:438 → 462
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:61 → 83
    RPEL; RPEL repeat

  4. NM_001195096.2 → NP_001182025.1  phosphatase and actin regulator 2 isoform C

    See identical proteins and their annotated locations for NP_001182025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AL713985, BE650511, CJ060660
    UniProtKB/TrEMBL
    A1L3S9, B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:449 → 473
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:72 → 94
    RPEL; RPEL repeat

  5. NM_001359294.1 → NP_001346223.1  phosphatase and actin regulator 2 isoform E

    Status: VALIDATED

    Source sequence(s)
    AL713985, BE650511, CJ060660
    Conserved Domains (2) summary
    smart00707
    Location:396 → 420
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:72 → 94
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    13083461..13350266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512673.5 → XP_006512736.1  phosphatase and actin regulator 2 isoform X8

    UniProtKB/TrEMBL
    B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:588 → 612
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  2. XM_006512676.3 → XP_006512739.1  phosphatase and actin regulator 2 isoform X13

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (1) summary
    smart00707
    Location:424 → 448
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  3. XM_006512675.3 → XP_006512738.1  phosphatase and actin regulator 2 isoform X10

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:451 → 475
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  4. XM_006512674.3 → XP_006512737.1  phosphatase and actin regulator 2 isoform X9

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:455 → 479
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  5. XM_006512671.3 → XP_006512734.1  phosphatase and actin regulator 2 isoform X6

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:504 → 528
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  6. XM_006512667.3 → XP_006512730.1  phosphatase and actin regulator 2 isoform X3

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:570 → 594
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  7. XM_006512665.3 → XP_006512728.1  phosphatase and actin regulator 2 isoform X1

    UniProtKB/TrEMBL
    B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:584 → 608
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  8. XM_006512677.4 → XP_006512740.1  phosphatase and actin regulator 2 isoform X15

    Conserved Domains (2) summary
    smart00707
    Location:381 → 405
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 83
    RPEL; RPEL repeat

  9. XM_036155728.1 → XP_036011621.1  phosphatase and actin regulator 2 isoform X12

    UniProtKB/TrEMBL
    B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:434 → 458
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 83
    RPEL; RPEL repeat

  10. XM_006512670.4 → XP_006512733.1  phosphatase and actin regulator 2 isoform X5

    UniProtKB/TrEMBL
    B1AVP0
    Related
    ENSMUSP00000101185.2, ENSMUST00000105546.8
    Conserved Domains (2) summary
    smart00707
    Location:518 → 542
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 83
    RPEL; RPEL repeat

  11. XM_036155729.1 → XP_036011622.1  phosphatase and actin regulator 2 isoform X14

    Conserved Domains (2) summary
    smart00707
    Location:392 → 416
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:73 → 94
    RPEL; RPEL repeat

  12. XM_036155730.1 → XP_036011623.1  phosphatase and actin regulator 2 isoform X16

    Conserved Domains (1) summary
    smart00707
    Location:365 → 389
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2

  13. XM_006512669.5 → XP_006512732.1  phosphatase and actin regulator 2 isoform X4

    UniProtKB/TrEMBL
    B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:529 → 553
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:73 → 94
    RPEL; RPEL repeat

  14. XM_030245000.1 → XP_030100860.1  phosphatase and actin regulator 2 isoform X11

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:455 → 479
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  15. XM_006512672.1 → XP_006512735.1  phosphatase and actin regulator 2 isoform X7

    UniProtKB/TrEMBL
    Q91VK6
    Conserved Domains (2) summary
    smart00707
    Location:504 → 528
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat

  16. XM_006512666.1 → XP_006512729.1  phosphatase and actin regulator 2 isoform X2

    UniProtKB/TrEMBL
    B1AVP0
    Conserved Domains (2) summary
    smart00707
    Location:584 → 608
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:132 → 153
    RPEL; RPEL repeat
Nucleotide Protein Strain
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