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Rab3ip RAB3A interacting protein [ Mus musculus (house mouse) ]

Gene ID: 216363, updated on 9-Dec-2024

Summary

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Official Symbol
Rab3ipprovided by MGI
Official Full Name
RAB3A interacting proteinprovided by MGI
Primary source
MGI:MGI:105933
See related
Ensembl:ENSMUSG00000064181 AllianceGenome:MGI:105933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabin3; Gtpat12; B230311A06
Summary
Enables identical protein binding activity and small GTPase binding activity. Predicted to be involved in several processes, including protein localization to motile cilium; protein targeting to membrane; and regulation of plasma membrane bounded cell projection assembly. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and proximal dendrite. Predicted to be active in Golgi to plasma membrane transport vesicle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human RAB3IP (RAB3A interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 46.3), testis adult (RPKM 22.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rab3ip in Genome Data Viewer
Location:
10 D2; 10 64.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116741685..116786361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116905780..116950456, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930579P08 gene Neighboring gene STARR-positive B cell enhancer mm9_chr10:116183775-116184076 Neighboring gene myelin regulatory factor-like Neighboring gene STARR-seq mESC enhancer starr_27965 Neighboring gene STARR-seq mESC enhancer starr_27966 Neighboring gene STARR-seq mESC enhancer starr_27967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:116367664-116367817 Neighboring gene predicted gene, 51782 Neighboring gene RIKEN cDNA 4933412E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10645 Neighboring gene RIKEN cDNA D630029K05 gene Neighboring gene predicted gene, 40768

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new strategy of gene trapping in ES cells using 3'RACE. Yoshida M, et al. Transgenic Res, 1995 Jul. PMID 7655516
  2. A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation. Li L, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Jul 20. PMID 37475549, Free PMC Article
  3. Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis. Walia V, et al. Dev Cell, 2019 Jul 22. PMID 31204173, Free PMC Article
  4. Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11. Vetter M, et al. Nat Struct Mol Biol, 2015 Sep. PMID 26258637
  5. The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting. Wang J, et al. J Cell Sci, 2015 Apr 1. PMID 25673879, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90794

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to motile cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in proximal dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rab-3A-interacting protein
Names
SSX2-interacting protein
gene trap PAT 12
rab3A-interacting protein
rabin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003950.3 → NP_001003950.1  rab-3A-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_001003950.1

    Status: VALIDATED

    Source sequence(s)
    AK045783, BC080289, BM938945, BY059863
    Consensus CDS
    CCDS24186.1
    UniProtKB/Swiss-Prot
    Q68EF0
    Related
    ENSMUSP00000020375.7, ENSMUST00000020375.7
    Conserved Domains (1) summary
    pfam08614
    Location:160 → 209
    ATG16; Autophagy protein 16 (ATG16)

  2. NM_001359645.1 → NP_001346574.1  rab-3A-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA980340, AK045783, AK152122, BM938945, BY059863
    Consensus CDS
    CCDS88090.1
    UniProtKB/TrEMBL
    A0A1W2P7K6
    Related
    ENSMUSP00000151708.2, ENSMUST00000219109.2
    Conserved Domains (2) summary
    COG4372
    Location:104 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116741685..116786361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513546.4 → XP_006513609.1  rab-3A-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006513609.1

    UniProtKB/TrEMBL
    A0A1W2P7K6
    Conserved Domains (2) summary
    COG4372
    Location:104 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p

  2. XM_030245041.1 → XP_030100901.1  rab-3A-interacting protein isoform X2

    UniProtKB/Swiss-Prot
    Q68EF0
    Conserved Domains (1) summary
    pfam08614
    Location:160 → 209
    ATG16; Autophagy protein 16 (ATG16)

  3. XM_006513544.2 → XP_006513607.1  rab-3A-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006513607.1

    UniProtKB/TrEMBL
    A0A1W2P7K6
    Conserved Domains (2) summary
    COG4372
    Location:104 → 240
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    pfam06428
    Location:173 → 241
    Sec2p; GDP/GTP exchange factor Sec2p

  4. XM_006513547.4 → XP_006513610.1  rab-3A-interacting protein isoform X3

    Conserved Domains (1) summary
    pfam06428
    Location:4 → 72
    Sec2p; GDP/GTP exchange factor Sec2p

  5. XM_017313908.2 → XP_017169397.1  rab-3A-interacting protein isoform X4

  6. XM_006513548.5 → XP_006513611.1  rab-3A-interacting protein isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EF0.1 GenPept UniProtKB/Swiss-Prot:Q68EF0

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