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Os9 amplified in osteosarcoma [ Mus musculus (house mouse) ]

Gene ID: 216440, updated on 9-Dec-2024

Summary

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Official Symbol
Os9provided by MGI
Official Full Name
amplified in osteosarcomaprovided by MGI
Primary source
MGI:MGI:1924301
See related
Ensembl:ENSMUSG00000040462 AllianceGenome:MGI:1924301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632413K17Rik
Summary
Predicted to enable protease binding activity. Predicted to be involved in several processes, including negative regulation of retrograde protein transport, ER to cytosol; protein retention in ER lumen; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human OS9 (OS9 endoplasmic reticulum lectin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 33.8), liver adult (RPKM 33.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Os9 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126928880..126957029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127094259..127121160, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126500339-126500526 Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E582 Neighboring gene cyclin dependent kinase 4 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40799 Neighboring gene STARR-positive B cell enhancer ABC_E253 Neighboring gene STARR-seq mESC enhancer starr_28206 Neighboring gene STARR-seq mESC enhancer starr_28208 Neighboring gene coenzyme Q4 homolog pseudogene Neighboring gene predicted gene, 23664

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Yu L, et al. Mol Med Rep, 2011 Jul-Aug. PMID 21523322
  2. The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. Ward BK, et al. J Cell Physiol, 2018 Jan. PMID 28419469
  3. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. Nakayama T, et al. FEBS Lett, 1999 Jun 18. PMID 10403379
  4. OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway. Seaayfan E, et al. J Biol Chem, 2016 Feb 26. PMID 26721884, Free PMC Article
  5. A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta. Litovchick L, et al. J Biol Chem, 2002 Sep 13. PMID 12093806

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing.
    Title: OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.
  2. The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation.
    Title: Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage.
  3. OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.
    Title: OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in protein retention in ER lumen ISO
Inferred from Sequence Orthology
more info
  
involved_in protein retention in ER lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein OS-9
Names
osteosarcoma amplified 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171026.1 → NP_001164497.1  protein OS-9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001164497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131760, AK028047, BF470029, CD802565, DV647242
    Consensus CDS
    CCDS48713.1
    UniProtKB/Swiss-Prot
    Q8K2C7
    UniProtKB/TrEMBL
    Q922S5
    Related
    ENSMUSP00000128914.2, ENSMUST00000164259.9
    Conserved Domains (2) summary
    pfam07915
    Location:110 → 181
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:175 → 236
    PRKCSH; Glucosidase II beta subunit-like protein

  2. NM_177614.3 → NP_808282.2  protein OS-9 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is a shorter, compared to isoform 1.
    Source sequence(s)
    AC131760, BF470029, BU703218, BY297242, CD802565, CX566458, DV660362
    Consensus CDS
    CCDS24229.1
    UniProtKB/TrEMBL
    Q922S5
    Related
    ENSMUSP00000079770.5, ENSMUST00000080975.6
    Conserved Domains (2) summary
    pfam07915
    Location:110 → 181
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:175 → 236
    PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126928880..126957029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245044.2 → XP_030100904.1  protein OS-9 isoform X2

    UniProtKB/TrEMBL
    Q922S5
    Conserved Domains (1) summary
    pfam07915
    Location:6 → 77
    PRKCSH; Glucosidase II beta subunit-like protein

  2. XM_011243420.2 → XP_011241722.1  protein OS-9 isoform X1

    UniProtKB/TrEMBL
    Q922S5
    Conserved Domains (2) summary
    PTZ00121
    Location:155 → 545
    PTZ00121; MAEBL; Provisional
    pfam07915
    Location:6 → 77
    PRKCSH; Glucosidase II beta subunit-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2C7.2 GenPept UniProtKB/Swiss-Prot:Q8K2C7

Gene LinkOut

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