Phlda1 pleckstrin homology like domain, family A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phlda1provided by MGI
Official Full Name: pleckstrin homology like domain, family A, member 1provided by MGI
Primary source: MGI:MGI:1096880
See related: Ensembl:ENSMUSG00000020205 AllianceGenome:MGI:1096880
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tdag; TDAG51; DT1P1B11
Summary: Predicted to enable phosphatidylinositol phosphate binding activity. Acts upstream of or within FasL biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb segment; respiratory system; and sensory organ. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 67.6), stomach adult (RPKM 50.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D1; 10 58.7 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (111342147..111344510)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (111506286..111508649)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
Title: Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
Title: Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis.
Title: FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis.
Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.
Title: Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.
TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.
Title: TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.
TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.
Title: TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.
Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
Title: Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARgamma in cerebral ischemia-reperfusion injury.
Title: PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARγ in cerebral ischemia-reperfusion injury.
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3beta Pathway.
Title: TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
Title: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U44088 (e-PCR)
- UniSTS:163487

U44088 (e-PCR)
- UniSTS:186293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within FasL biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pleckstrin homology-like domain family A member 1

Names: PQ-rich protein; PQR protein; T-cell death associated; T-cell death-associated gene 51 protein; proline- and glutamine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009344.3 → NP_033370.2 pleckstrin homology-like domain family A member 1

See identical proteins and their annotated locations for NP_033370.2

Status: VALIDATED

Source sequence(s)

BY378082, U44088

Consensus CDS

CCDS24167.2

UniProtKB/Swiss-Prot

Q3TY48, Q3UG87, Q62392

Related

ENSMUSP00000132815.2, ENSMUST00000164773.2

Conserved Domains (2) summary

smart00233
Location:154 → 261

PH; Pleckstrin homology domain

pfam12286
Location:250 → 274

DUF3622; Protein of unknown function (DUF3622)