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FABP3 fatty acid binding protein 3 [ Homo sapiens (human) ]

Gene ID: 2170, updated on 26-Nov-2024

Summary

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Official Symbol
FABP3provided by HGNC
Official Full Name
fatty acid binding protein 3provided by HGNC
Primary source
HGNC:HGNC:3557
See related
Ensembl:ENSG00000121769 MIM:134651; AllianceGenome:HGNC:3557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDGI; FABP11; H-FABP; M-FABP; O-FABP
Summary
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Biased expression in heart (RPKM 311.6), brain (RPKM 22.8) and 1 other tissue See more
Orthologs
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Genomic context

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See FABP3 in Genome Data Viewer
Location:
1p35.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31359588..31373076, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31211868..31225340, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31838100..31845923, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 566 Neighboring gene Sharpr-MPRA regulatory region 5533 Neighboring gene sodium/potassium transporting ATPase interacting 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31671341-31671841 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:31688981-31689480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31695101-31695601 Neighboring gene small nuclear ribonucleoprotein U5 subunit 40 Neighboring gene MPRA-validated peak156 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 641 Neighboring gene zinc finger CCHC-type containing 17 Neighboring gene Sharpr-MPRA regulatory region 7682 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:31827736-31827903 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:31839312-31839494 Neighboring gene Sharpr-MPRA regulatory region 13821 Neighboring gene uncharacterized LOC124903892 Neighboring gene Sharpr-MPRA regulatory region 3310 Neighboring gene uncharacterized LOC105378623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support. Cabiati M, et al. Biomark Med, 2013 Jun. PMID 23734811
  2. Heart-type fatty acid binding protein (H-FABP): relationship with arterial intima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolism. Karbek B, et al. Cardiovasc Diabetol, 2011 May 2. PMID 21535886, Free PMC Article
  3. Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease. Hayabuchi Y, et al. Circ J, 2011. PMID 21617322
  4. Heart fatty acid-binding protein offers similar diagnostic performance to high-sensitivity troponin T in emergency room patients presenting with chest pain. Inoue K, et al. Circ J, 2011. PMID 21937835
  5. Diagnostic accuracy of quantitative heart-fatty acid binding protein assays compared with Cardiodetect(®) in the early detection of acute coronary syndrome. Charpentier S, et al. Arch Cardiovasc Dis, 2011 Oct. PMID 22044705

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fatty acid binding to the human transport proteins FABP3, FABP4, and FABP5 from a Ligand's perspective.
    Title: Fatty acid binding to the human transport proteins FABP3, FABP4, and FABP5 from a Ligand's perspective.
  2. Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.
    Title: Fatty acid-binding protein-3 and renal function decline in patients with chronic coronary syndrome.
  3. Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
    Title: Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19.
  4. Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.
    Title: Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure.
  5. Anti bacterial function of secreted human FABP3.
    Title: Anti bacterial function of secreted human FABP3.
  6. Plasma Galectin-3 and H-FABP correlate with poor physical performance in patients with congestive heart failure.
    Title: Plasma Galectin-3 and H-FABP correlate with poor physical performance in patients with congestive heart failure.
  7. Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity.
    Title: Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity.
  8. Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction.
    Title: Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction.
  9. Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
    Title: Fatty acid-binding proteins 3 and 5 are involved in the initiation of mitochondrial damage in ischemic neurons.
  10. FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts.
    Title: FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts.
Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables long-chain fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oleic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular lipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-chain fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of long-chain fatty acid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of phospholipid biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid-binding protein, heart
Names
epididymis secretory sperm binding protein
fatty acid binding protein 11
fatty acid binding protein 3, muscle and heart
heart-type fatty acid-binding protein
mammary-derived growth inhibitor
muscle fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047049.1 RefSeqGene

    Range
    5208..13031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320996.2 → NP_001307925.1  fatty acid-binding protein, heart isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL451070, BF576953, BI752278, BP194697, CN283506
    UniProtKB/TrEMBL
    Q6IBD7, S4R371
    Conserved Domains (1) summary
    pfam00061
    Location:6 → 143
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_004102.5 → NP_004093.1  fatty acid-binding protein, heart isoform 2

    See identical proteins and their annotated locations for NP_004093.1

    Status: REVIEWED

    Source sequence(s)
    AL451070, BC007021
    Consensus CDS
    CCDS342.1
    UniProtKB/Swiss-Prot
    B2RAB6, P05413, Q5VV93, Q99957
    UniProtKB/TrEMBL
    A0A384MDY5, Q6IBD7, S4R371
    Related
    ENSP00000362817.2, ENST00000373713.7
    Conserved Domains (1) summary
    cd19466
    Location:4 → 131
    FABP3; fatty acid binding protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31359588..31373076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541007.4 → XP_011539309.1  fatty acid-binding protein, heart isoform X1

    See identical proteins and their annotated locations for XP_011539309.1

    UniProtKB/TrEMBL
    S4R371
    Conserved Domains (1) summary
    cl10502
    Location:4 → 116
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31211868..31225340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335131.1 → XP_054191106.1  fatty acid-binding protein, heart isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05413.4 GenPept UniProtKB/Swiss-Prot:P05413

Gene LinkOut

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