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Stxbp6 syntaxin binding protein 6 (amisyn) [ Mus musculus (house mouse) ]

Gene ID: 217517, updated on 9-Aug-2024

Summary

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Official Symbol
Stxbp6provided by MGI
Official Full Name
syntaxin binding protein 6 (amisyn)provided by MGI
Primary source
MGI:MGI:2384963
See related
Ensembl:ENSMUSG00000046314 AllianceGenome:MGI:2384963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gut; hindlimb; olfactory epithelium; and tail. Orthologous to human STXBP6 (syntaxin binding protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 19.0), cortex adult (RPKM 9.8) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Stxbp6 in Genome Data Viewer
Location:
12 B3; 12 20.71 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (44899267..45121248, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (44852484..45075118, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32040 Neighboring gene STARR-seq mESC enhancer starr_32041 Neighboring gene STARR-seq mESC enhancer starr_32042 Neighboring gene predicted gene, 51975 Neighboring gene predicted gene, 53718 Neighboring gene predicted gene, 33548 Neighboring gene STARR-seq mESC enhancer starr_32043 Neighboring gene Nanog homeobox pseudogene Neighboring gene predicted gene, 38487 Neighboring gene predicted gene, 24731 Neighboring gene STARR-seq mESC enhancer starr_32044 Neighboring gene predicted gene, 57590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion. Collins SC, et al. Diabetes, 2016 Jul. PMID 26993066, Free PMC Article
  2. Genetic dissection of the fatty liver QTL Fl1sa by using congenic mice and identification of candidate genes in the liver and epididymal fat. Suzuki M, et al. BMC Genet, 2016 Nov 17. PMID 27855657, Free PMC Article
  3. Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Huang TN, et al. Nat Neurosci, 2014 Feb. PMID 24441682
  4. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
  5. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains. Vadasz C, et al. Neurochem Res, 2007 Jul. PMID 17273929, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30948

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntaxin-binding protein 6
Names
amisyn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411381.1 → NP_001398310.1  syntaxin-binding protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159234, AK158779
    UniProtKB/TrEMBL
    Q3TYA4
    Related
    ENSMUSP00000112551.2, ENSMUST00000120531.8

  2. NM_001411382.1 → NP_001398311.1  syntaxin-binding protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582
    UniProtKB/TrEMBL
    Q3TYA4

  3. NM_001411383.1 → NP_001398312.1  syntaxin-binding protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582

  4. NM_001411384.1 → NP_001398313.1  syntaxin-binding protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582

  5. NM_144552.4 → NP_653135.2  syntaxin-binding protein 6 isoform 1

    See identical proteins and their annotated locations for NP_653135.2

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582
    Consensus CDS
    CCDS25898.1
    UniProtKB/TrEMBL
    Q3TYA4
    Related
    ENSMUSP00000052639.7, ENSMUST00000053768.14
    Conserved Domains (2) summary
    cd14681
    Location:2 → 131
    PH-STXBP6; PH-like domain of Syntaxin binding protein 6
    cd15892
    Location:149 → 210
    R-SNARE_STXBP6; SNARE domain of STXBP6

RNA

  1. NR_177243.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582

  2. NR_177244.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159234, AC159616, CR974582

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    44899267..45121248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157308.1 → XP_036013201.1  syntaxin-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    Q3TYA4
    Conserved Domains (2) summary
    cd14681
    Location:2 → 131
    PH-STXBP6; PH-like domain of Syntaxin binding protein 6
    cd15892
    Location:149 → 210
    R-SNARE_STXBP6; SNARE domain of STXBP6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3T5.1 GenPept UniProtKB/Swiss-Prot:Q8R3T5

Gene LinkOut

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