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Mbip MAP3K12 binding inhibitory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 217588, updated on 4-Jan-2025

Summary

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Official Symbol
Mbipprovided by MGI
Official Full Name
MAP3K12 binding inhibitory protein 1provided by MGI
Primary source
MGI:MGI:1918320
See related
Ensembl:ENSMUSG00000021028 AllianceGenome:MGI:1918320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933408E06Rik
Summary
Predicted to enable identical protein binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in nucleus. Part of ATAC complex. Is expressed in lung and telencephalon. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E14 (RPKM 9.9), CNS E11.5 (RPKM 9.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Mbip in Genome Data Viewer
Location:
12 C1; 12 24.3 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56375091..56392681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56328306..56345933, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19990 Neighboring gene predicted gene, 46351 Neighboring gene STARR-seq mESC enhancer starr_32208 Neighboring gene predicted gene, 53723 Neighboring gene STARR-positive B cell enhancer ABC_E2385 Neighboring gene cytochrome c oxidase subunit 6C2 Neighboring gene STARR-positive B cell enhancer ABC_E5330 Neighboring gene STARR-positive B cell enhancer ABC_E8887 Neighboring gene STARR-positive B cell enhancer ABC_E10750 Neighboring gene predicted gene, 18027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs. Ochieng JK, et al. Oncogene, 2020 Oct. PMID 32963352, Free PMC Article
  2. The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration. Zhang X, et al. FEBS Lett, 2004 Feb 13. PMID 14960307
  3. Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. Tucker ES, et al. J Neurosci, 2008 Sep 17. PMID 18799682, Free PMC Article
  4. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  5. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs.
    Title: MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7681

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP3K12-binding inhibitory protein 1
Names
MAPK upstream kinase-binding inhibitory protein
MUK-binding inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145442.2 → NP_663417.1  MAP3K12-binding inhibitory protein 1

    Status: VALIDATED

    Source sequence(s)
    AC154714, AK077125
    Consensus CDS
    CCDS25920.1
    UniProtKB/Swiss-Prot
    Q3TBM3, Q99LQ1
    Related
    ENSMUSP00000021416.8, ENSMUST00000021416.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    56375091..56392681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246648.2 → XP_030102508.1  MAP3K12-binding inhibitory protein 1 isoform X3

  2. XM_006515674.5 → XP_006515737.1  MAP3K12-binding inhibitory protein 1 isoform X2

  3. XM_006515673.5 → XP_006515736.1  MAP3K12-binding inhibitory protein 1 isoform X1

  4. XM_017315023.3 → XP_017170512.1  MAP3K12-binding inhibitory protein 1 isoform X5

  5. XM_017315021.3 → XP_017170510.1  MAP3K12-binding inhibitory protein 1 isoform X4

RNA

  1. XR_004937488.1 RNA Sequence

  2. XR_004937487.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LQ1.1 GenPept UniProtKB/Swiss-Prot:Q99LQ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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