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Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 [ Mus musculus (house mouse) ]

Gene ID: 21762, updated on 30-Apr-2024

Summary

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Official Symbol
Psmd2provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2provided by MGI
Primary source
MGI:MGI:1096584
See related
Ensembl:ENSMUSG00000006998 AllianceGenome:MGI:1096584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex190; TEG-190; 9430095H01Rik
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in several structures, including central nervous system and retina. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 102.9), CNS E11.5 (RPKM 75.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psmd2 in Genome Data Viewer
Location:
16 A3; 16 12.49 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20469872..20482164)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20651122..20663414)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene endothelin converting enzyme 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
  2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
  3. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
  4. An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity. Stanhill A, et al. Mol Cell, 2006 Sep 15. PMID 16973439
  5. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in proteasome storage granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 2
Names
26S proteasome regulatory subunit RPN1
26S proteasome regulatory subunit S2
26S proteasome subunit p97
testis expressed gene 190

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134101.2 → NP_598862.1  26S proteasome non-ATPase regulatory subunit 2

    See identical proteins and their annotated locations for NP_598862.1

    Status: VALIDATED

    Description
    Transcript Variant: This transcript (1) is the protein-coding transcript variant.
    Source sequence(s)
    BC024830, BY307723
    Consensus CDS
    CCDS28053.1
    UniProtKB/Swiss-Prot
    Q8VDM4
    UniProtKB/TrEMBL
    Q3TI61, Q3TKV1, Q3TW71, Q3TXV1
    Related
    ENSMUSP00000007212.9, ENSMUST00000007212.9
    Conserved Domains (1) summary
    COG5110
    Location:7 → 906
    RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_027485.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a codon exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC024830, BC033325, BY307723
    Related
    ENSMUST00000172207.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20469872..20482164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249039.1 → XP_030104899.1  26S proteasome non-ATPase regulatory subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDM4
    UniProtKB/TrEMBL
    Q3TI61, Q3TKV1, Q3TW71, Q3TXV1
    Conserved Domains (1) summary
    COG5110
    Location:7 → 906
    RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDM4.1 GenPept UniProtKB/Swiss-Prot:Q8VDM4

Gene LinkOut

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