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Sipa1l1 signal-induced proliferation-associated 1 like 1 [ Mus musculus (house mouse) ]

Gene ID: 217692, updated on 9-Dec-2024

Summary

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Official Symbol
Sipa1l1provided by MGI
Official Full Name
signal-induced proliferation-associated 1 like 1provided by MGI
Primary source
MGI:MGI:2443679
See related
Ensembl:ENSMUSG00000042700 AllianceGenome:MGI:2443679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spar; mKIAA0440; 4931426N11Rik
Summary
Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and regulation of axonogenesis. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 37.5), cortex adult (RPKM 30.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Sipa1l1 in Genome Data Viewer
Location:
12 D1; 12 38.14 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (82216138..82498560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (82169377..82451786)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pecanex 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:83072406-83072559 Neighboring gene STARR-seq mESC enhancer starr_32682 Neighboring gene predicted gene, 30799 Neighboring gene STARR-seq mESC enhancer starr_32683 Neighboring gene STARR-positive B cell enhancer ABC_E7158 Neighboring gene STARR-positive B cell enhancer ABC_E4035 Neighboring gene STARR-positive B cell enhancer ABC_E11517 Neighboring gene predicted gene, 30916 Neighboring gene STARR-seq mESC enhancer starr_32692 Neighboring gene STARR-seq mESC enhancer starr_32693 Neighboring gene predicted gene, 51987 Neighboring gene predicted gene, 31064 Neighboring gene predicted gene, 30966 Neighboring gene general transcription factor II A, 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling. Matsuura K, et al. J Neurosci, 2022 Mar 23. PMID 35121636, Free PMC Article
  2. Hippocampal spine-associated Rap-specific GTPase-activating protein induces enhancement of learning and memory in postnatally hypoxia-exposed mice. Lu XJ, et al. Neuroscience, 2009 Aug 18. PMID 19442707, Free PMC Article
  3. Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis. Wang PJ, et al. J Biol Chem, 2017 May 12. PMID 28336531, Free PMC Article
  4. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. Richter M, et al. J Neurosci, 2007 Dec 19. PMID 18094260, Free PMC Article
  5. Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation. Mihalas AB, et al. J Neurosci, 2013 Oct 16. PMID 24133254, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.
    Title: SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.
  2. PDZ domain-containing protein Sipa1l1 (signal-induced proliferation-associated 1 like 1) binds to the cytoplasmic PDZ-ligand motif of aquaporin-2 and accelerates its endocytosis in the absence of vasopressin
    Title: Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis.
  3. Our data establish an integral feedback loop involving NF-kappaB, Plks, and SPAR that regulates the end point of homeostatic synaptic adaptation to elevated activity and implicate a transcription factor in the regulation of homeostatic synaptic responses.
    Title: Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation.
  4. SPAR is functionally required for synaptic plasticity and contributes to the IH-induced enhancement of spatial learning and memory in postnatal developing mice.
    Title: Hippocampal spine-associated Rap-specific GTPase-activating protein induces enhancement of learning and memory in postnatally hypoxia-exposed mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal-induced proliferation-associated 1-like protein 1
Names
SIPA1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167983.1 → NP_001161455.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001161455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to variant 1, resulting in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK078420, AK122284, BC058681, BP765364
    Consensus CDS
    CCDS49105.1
    UniProtKB/Swiss-Prot
    Q8C0T5
    Related
    ENSMUSP00000152356.2, ENSMUST00000222298.2
    Conserved Domains (3) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  2. NM_001407402.1 → NP_001394331.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  3. NM_001407403.1 → NP_001394332.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5
    Related
    ENSMUSP00000131030.3, ENSMUST00000166429.9

  4. NM_001407404.1 → NP_001394333.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5

  5. NM_001407405.1 → NP_001394334.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5

  6. NM_001407406.1 → NP_001394335.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC156643
    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5
    Related
    ENSMUSP00000061014.7, ENSMUST00000053969.7

  7. NM_001407407.1 → NP_001394336.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC156643

  8. NM_001407408.1 → NP_001394337.1  signal-induced proliferation-associated 1-like protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  9. NM_001407409.1 → NP_001394338.1  signal-induced proliferation-associated 1-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  10. NM_001407410.1 → NP_001394339.1  signal-induced proliferation-associated 1-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  11. NM_001407411.1 → NP_001394340.1  signal-induced proliferation-associated 1-like protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    UniProtKB/TrEMBL
    Q4VBF8
    Related
    ENSMUSP00000152681.2, ENSMUST00000220963.2

  12. NM_001407412.1 → NP_001394341.1  signal-induced proliferation-associated 1-like protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    UniProtKB/TrEMBL
    Q4VBF8

  13. NM_001407413.1 → NP_001394342.1  signal-induced proliferation-associated 1-like protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  14. NM_001407414.1 → NP_001394343.1  signal-induced proliferation-associated 1-like protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  15. NM_001407415.1 → NP_001394344.1  signal-induced proliferation-associated 1-like protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643

  16. NM_172579.4 → NP_766167.2  signal-induced proliferation-associated 1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_766167.2

    Status: VALIDATED

    Source sequence(s)
    AC122227, AC130222, AC156643
    Consensus CDS
    CCDS26026.1
    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    82216138..82498560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244060.4 → XP_011242362.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242362.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  2. XM_011244067.4 → XP_011242369.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1728 → 1783
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1500 → 1740
    SPAR_C; C-terminal domain of SPAR protein

  3. XM_011244061.3 → XP_011242363.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242363.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  4. XM_036157315.1 → XP_036013208.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1716 → 1771
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1728
    SPAR_C; C-terminal domain of SPAR protein

  5. XM_017315025.2 → XP_017170514.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q6PDI8, Q80U02, Q8C026, Q8C0T5
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  6. XM_017315027.2 → XP_017170516.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  7. XM_017315026.2 → XP_017170515.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  8. XM_030246655.1 → XP_030102515.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  9. XM_030246653.2 → XP_030102513.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  10. XM_030246652.1 → XP_030102512.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  11. XM_030246656.1 → XP_030102516.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  12. XM_011244064.4 → XP_011242366.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242366.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  13. XM_011244066.4 → XP_011242368.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242368.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  14. XM_011244063.4 → XP_011242365.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242365.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  15. XM_030246654.2 → XP_030102514.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  16. XM_030246657.2 → XP_030102517.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1235 → 1290
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1006 → 1247
    SPAR_C; C-terminal domain of SPAR protein

  17. XM_036157314.1 → XP_036013207.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  18. XM_011244062.2 → XP_011242364.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011242364.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  19. XM_006515684.3 → XP_006515747.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515747.1

    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1729 → 1784
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1496 → 1741
    SPAR_C; C-terminal domain of SPAR protein

  20. XM_017315029.1 → XP_017170518.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

    Conserved Domains (4) summary
    cd00992
    Location:428 → 498
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:104 → 284
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1204 → 1259
    ZapB; Cell division protein ZapB
    pfam11881
    Location:975 → 1216
    SPAR_C; C-terminal domain of SPAR protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0T5.2 GenPept UniProtKB/Swiss-Prot:Q8C0T5

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