Zfp503 zinc finger protein 503 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp503provided by MGI
Official Full Name: zinc finger protein 503provided by MGI
Primary source: MGI:MGI:1353644
See related: Ensembl:ENSMUSG00000039081 AllianceGenome:MGI:1353644
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zpo2; Nolz1; Nolz-1; Znf503; B830002A16Rik
Summary: Predicted to enable metal ion binding activity. Involved in G1 to G0 transition involved in cell differentiation and neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; limb bud; and sensory organ. Orthologous to human ZNF503 (zinc finger protein 503). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 54.1), adrenal adult (RPKM 48.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 12.0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (22034030..22039669, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (21983959..21989601, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure.
Title: Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure.
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.
Title: Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.
These results reveal that CD93 is a negative regulator of the onset of astrogenesis and provide insight into therapy for psychiatric disorders.
Title: CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain.
We have identified ZPO2 as a negative regulator of GATA3, thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development.
Title: ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression.
ZNF503 promotes mammary cell proliferation and migration.
Title: The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion.
ectopic expression of Nolz-1 in neural progenitors promotes cell cycle exit/premature neuronal differentiation and induces abnormal apoptosis in the developing telencephalon.
Title: Ectopic expression of nolz-1 in neural progenitors promotes cell cycle exit/premature neuronal differentiation accompanying with abnormal apoptosis in the developing mouse telencephalon.
Taken together, our study suggests that Nolz-1 serves as a marker for early differentiating striatal projection neurons and that Nolz-1 may regulate development of striatal projection neurons.
Title: Cell type-selective expression of the zinc finger-containing gene Nolz-1/Zfp503 in the developing mouse striatum.
our study suggests that UREA and UREB may function as evolutionarily conserved cis-regulatory elements that coordinate with other cis-elements to regulate spatiotemporal expression of Nolz-1 in different tissue organs during mouse embryogenesis.
Title: Identification of two evolutionarily conserved 5' cis-elements involved in regulating spatiotemporal expression of Nolz-1 during mouse embryogenesis.
Nolz-1 may involve in regulation of various developmental processes, including regional patterning and cell-type specification and differentiation in the developing mouse hindbrain.
Title: Region- and cell type-selective expression of the evolutionarily conserved Nolz-1/zfp503 gene in the developing mouse hindbrain.
This study suggested that Nolz1 might act downstream of Gsx2 to regulate RA-induced neurogenesis.
Title: Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

UniSTS:237136 (e-PCR)
- UniSTS:237136

Zfp503 (e-PCR), detects polymorphism
- UniSTS:507338

RH135913 (e-PCR)
- UniSTS:209911

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition involved in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1 to G0 transition involved in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 503

Names: zinc finger protein Nolz-1; zinc-finger protein NOLZ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145459.3 → NP_663434.2 zinc finger protein 503

See identical proteins and their annotated locations for NP_663434.2

Status: PROVISIONAL

Source sequence(s)

BC066027

Consensus CDS

CCDS36822.1

UniProtKB/Swiss-Prot

Q7TMA2, Q8VCV4

Related

ENSMUSP00000046641.8, ENSMUST00000043409.9

Conserved Domains (2) summary

sd00017
Location:522 → 548

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12402
Location:361 → 421

nlz1; NocA-like zinc-finger protein 1