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Tmpo thymopoietin [ Mus musculus (house mouse) ]

Gene ID: 21917, updated on 9-Dec-2024

Summary

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Official Symbol
Tmpoprovided by MGI
Official Full Name
thymopoietinprovided by MGI
Primary source
MGI:MGI:106920
See related
Ensembl:ENSMUSG00000019961 AllianceGenome:MGI:106920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TP; LAP2; 5630400D24Rik
Summary
Enables identical protein binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nuclear envelope. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 41.2), limb E14.5 (RPKM 32.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tmpo in Genome Data Viewer
Location:
10 C2; 10 45.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90983433..91017614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91147571..91181752, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene IKBKB interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene STARR-seq mESC enhancer starr_27546 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene RIKEN cDNA 4930534H03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitous expression of a cloned murine thymopoietin cDNA. Theodor L, et al. Acta Haematol, 1997. PMID 9066710
  2. Identification of phosphorylation sites in native lamina-associated polypeptide 2 beta. Dreger M, et al. Biochemistry, 1999 Jul 20. PMID 10413518
  3. Multiple novel functions of lamina associated polypeptide 2α in striated muscle. Gotic I, et al. Nucleus, 2010 Sep-Oct. PMID 21326822, Free PMC Article
  4. Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination. Gotic I, et al. Stem Cells, 2010 Mar 31. PMID 20039368
  5. Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α. Cohen TV, et al. Hum Mol Genet, 2013 Jul 15. PMID 23535822, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased expression of LAP2beta eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
    Title: Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
  2. Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity.
    Title: Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.
  3. Lifespan and body mass were increased in Lmna(-/-)Lap2alpha(-/-) mice compared with Lmna deficient mice.
    Title: Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α.
  4. Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C in the regulation of tissue progenitor cells are not affected in Lmna(DeltaK32/DeltaK32) mice.
    Title: The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice.
  5. LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific gene expression during muscle regeneration, muscle remodeling and stress response.
    Title: Multiple novel functions of lamina associated polypeptide 2α in striated muscle.
  6. TSLP diverts airway tolerance against ovalbumin (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.
    Title: Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells.
  7. The age-related down-regulation of Wnt4 (and subsequently FoxN1), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.
    Title: Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
  8. Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.
    Title: Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination.
  9. Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 and MEF2c, while dstrophin deficiency in Mdx mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.
    Title: Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.
  10. Loss of LAP2-Lmna complexes causes erythroid and epidermal progenitor hyperproliferation.
    Title: Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
lamina-associated polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080129.3 → NP_001073598.1  lamina-associated polypeptide 2 isoform epsilon

    See identical proteins and their annotated locations for NP_001073598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains most exons of this gene and encodes isoform (epsilon).
    Source sequence(s)
    AC122188, AC140410
    Consensus CDS
    CCDS36035.1
    UniProtKB/Swiss-Prot
    Q3UCI5, Q61029, Q61030, Q61031, Q61032
    UniProtKB/TrEMBL
    Q3U7B3, Q3UR33
    Related
    ENSMUSP00000072092.8, ENSMUST00000072239.14
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  2. NM_001080130.3 → NP_001073599.1  lamina-associated polypeptide 2 isoform delta

    See identical proteins and their annotated locations for NP_001073599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (delta) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AC122188, AC140410
    Consensus CDS
    CCDS36034.1
    UniProtKB/TrEMBL
    Q3TNH0, Q3U7B3, Q3UR33
    Related
    ENSMUSP00000089864.7, ENSMUST00000092219.14
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  3. NM_001080131.3 → NP_001073600.1  lamina-associated polypeptide 2 isoform gamma

    See identical proteins and their annotated locations for NP_001073600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (gamma) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AC122188, AC140410
    Consensus CDS
    CCDS36033.1
    UniProtKB/TrEMBL
    Q3U7B3, Q3UR33
    Related
    ENSMUSP00000096956.5, ENSMUST00000099355.12
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  4. NM_001080132.3 → NP_001073601.1  lamina-associated polypeptide 2 isoform beta

    See identical proteins and their annotated locations for NP_001073601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (beta) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AC122188, AC140410
    Consensus CDS
    CCDS36032.1
    UniProtKB/Swiss-Prot
    Q61029
    Related
    ENSMUSP00000100930.4, ENSMUST00000105293.11
    Conserved Domains (2) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein

  5. NM_001283048.2 → NP_001269977.1  lamina-associated polypeptide 2 isoform omega

    See identical proteins and their annotated locations for NP_001269977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (omega) has a much shorter N-terminus, compared to isoform epsilon. Variants 7-14 all encode the same isoform (omega).
    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1
    Conserved Domains (1) summary
    COG1426
    Location:26 → 99
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

  6. NM_001428854.1 → NP_001415783.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  7. NM_001428855.1 → NP_001415784.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  8. NM_001428856.1 → NP_001415785.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  9. NM_001428857.1 → NP_001415786.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  10. NM_001428858.1 → NP_001415787.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  11. NM_001428859.1 → NP_001415788.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  12. NM_001428860.1 → NP_001415789.1  lamina-associated polypeptide 2 isoform omega

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410
    UniProtKB/TrEMBL
    Q3TXQ1

  13. NM_011605.4 → NP_035735.2  lamina-associated polypeptide 2 isoform alpha

    See identical proteins and their annotated locations for NP_035735.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks several exons but has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (alpha) is longer and has a distinct C-terminus, compared to isoform epsilon.
    Source sequence(s)
    AC122188, AC140410
    Consensus CDS
    CCDS24122.1
    UniProtKB/Swiss-Prot
    B2RUB9, Q61028, Q61033
    Related
    ENSMUSP00000020123.6, ENSMUST00000020123.7
    Conserved Domains (3) summary
    cd12940
    Location:110 → 138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:2 → 49
    Thymopoietin; Thymopoietin protein
    pfam11560
    Location:459 → 692
    LAP2alpha; Lamina-associated polypeptide 2 alpha

RNA

  1. NR_190513.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122188

  2. NR_190514.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410

  3. NR_190515.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122188, AC140410

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    90983433..91017614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245061.1 → XP_030100921.1  lamina-associated polypeptide 2 isoform X1

    Conserved Domains (1) summary
    COG1426
    Location:26 → 99
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006513590.4 → XP_006513653.1  lamina-associated polypeptide 2 isoform X1

    Conserved Domains (1) summary
    COG1426
    Location:26 → 99
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080134.1: Suppressed sequence

    Description
    NM_001080134.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61029.4 GenPept UniProtKB/Swiss-Prot:Q61029
Q61033.4 GenPept UniProtKB/Swiss-Prot:Q61033

Gene LinkOut

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