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Tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [ Mus musculus (house mouse) ]

Gene ID: 21927, updated on 9-Dec-2024

Summary

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Official Symbol
Tnfaip1provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 1 (endothelial)provided by MGI
Primary source
MGI:MGI:104961
See related
Ensembl:ENSMUSG00000017615 AllianceGenome:MGI:104961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edp1; Edp-1; Tnfip1; Bacurd2
Summary
Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; positive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lung adult (RPKM 35.5), large intestine adult (RPKM 31.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfaip1 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78413676..78427122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78522850..78536270, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene polymerase (DNA-directed), delta interacting protein 2 Neighboring gene intraflagellar transport 20 Neighboring gene transmembrane protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E3979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway. Xu C, et al. J Physiol Biochem, 2024 Aug. PMID 38878215
  2. TNFAIP1 contributes to the neurotoxicity induced by Aβ25-35 in Neuro2a cells. Liu N, et al. BMC Neurosci, 2016 Jul 18. PMID 27430312, Free PMC Article
  3. TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells. Yi J, et al. Neurotox Res, 2020 Jun. PMID 32335808
  4. Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus. Liu H, et al. Int J Mol Med, 2014 Jul. PMID 24737445
  5. Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. Gladwyn-Ng I, et al. Neural Dev, 2016 Mar 11. PMID 26969432, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway.
    Title: TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway.
  2. MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
    Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
  3. Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
    Title: Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
  4. TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
    Title: TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
  5. Results demonstrated that TNFAIP1 was significantly upregulated by Abeta25-35 in mouse primary cortical neurons and N2a cells, and TNFAIP1 may be a key player that mediated Abeta25-35-induced neurotoxicity by inactivating the Akt/CREB signaling pathway, and in turn downregulating anti-apoptotic protein Bcl-2.
    Title: TNFAIP1 contributes to the neurotoxicity induced by Aβ25-35 in Neuro2a cells.
  6. ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells.
    Title: miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells.
  7. Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons.
    Title: Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
  8. Bacurd2 influences the multipolar-to-bipolar transition of radially migrating neurons in a cell autonomous fashion. Bacurd2 and Rnd2 interact to promote radial migration within the embryonic cortex.
    Title: Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
  9. Estrogen and ERbeta regulate Tnfaip1 expression in mouse hippocampus.
    Title: Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Names
BTB/POZ domain-containing protein TNFAIP1
tumor necrosis factor induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159392.1 → NP_001152864.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

    See identical proteins and their annotated locations for NP_001152864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034305, AK147809, AK168805, BY060883, CB205355
    Consensus CDS
    CCDS25110.1
    UniProtKB/Swiss-Prot
    O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
    Related
    ENSMUSP00000103912.3, ENSMUST00000108277.3
    Conserved Domains (2) summary
    smart00225
    Location:29 → 127
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:30 → 120
    BTB_2; BTB/POZ domain

  2. NM_009395.4 → NP_033421.3  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

    See identical proteins and their annotated locations for NP_033421.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034305, AK147809, AK168805, BY329500, CB205355
    Consensus CDS
    CCDS25110.1
    UniProtKB/Swiss-Prot
    O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
    Related
    ENSMUSP00000017759.3, ENSMUST00000017759.9
    Conserved Domains (2) summary
    smart00225
    Location:29 → 127
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:30 → 120
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78413676..78427122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245918.2 → XP_030101778.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

    Conserved Domains (1) summary
    cl38908
    Location:1 → 25
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_030245919.2 → XP_030101779.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

    Conserved Domains (1) summary
    cl38908
    Location:1 → 25
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70479.1 GenPept UniProtKB/Swiss-Prot:O70479

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