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DDIAS DNA damage induced apoptosis suppressor [ Homo sapiens (human) ]

Gene ID: 220042, updated on 27-Nov-2024

Summary

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Official Symbol
DDIASprovided by HGNC
Official Full Name
DNA damage induced apoptosis suppressorprovided by HGNC
Primary source
HGNC:HGNC:26351
See related
Ensembl:ENSG00000165490 MIM:618045; AllianceGenome:HGNC:26351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
noxin; C11orf82
Summary
Involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 5.9), lymph node (RPKM 1.9) and 14 other tissues See more
Orthologs
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Genomic context

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See DDIAS in Genome Data Viewer
Location:
11q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (82901736..82934659)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (82825989..82871120)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (82612778..82645701)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 Neighboring gene prolylcarboxypeptidase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:82569102-82570301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5335 Neighboring gene MIR3 retrotransposon enhancer-blocking element Neighboring gene uncharacterized LOC124902602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5337 Neighboring gene ribosomal protein L7a pseudogene 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5340 Neighboring gene RAB30, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5341 Neighboring gene small nucleolar RNA, H/ACA box 70E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells. Im JY, et al. Oncogene, 2018 Mar. PMID 29242605
  2. DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion. Im JY, et al. Biochim Biophys Acta, 2016 Nov. PMID 27412911
  3. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma. Zhang ZZ, et al. Int J Cancer, 2015 Aug 15. PMID 25612832
  4. DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer. Im JY, et al. Biochim Biophys Acta, 2016 Jan. PMID 26493727
  5. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. Won KJ, et al. Int J Cancer, 2014 Jun 1. PMID 24214091

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High DDIAS expression suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in lung and liver cancer.
    Title: DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.
  2. these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents
    Title: Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.
  3. Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
    Title: Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway.
  4. EGF activates the ERK5/MEF2 pathway, which in turn induces DDIAS expression to promote cancer cell invasion by activating beta-catenin target genes
    Title: DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion.
  5. DDIAS is a target of NFATc1 and is associated with cisplatin resistance in lung cancer cells.
    Title: DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer.
  6. NOXIN overexpression, as a result of genomic DNA gain or amplification, promotes HCC tumorigenesis by accelerating DNA synthesis and cell cycle progression, where NOXIN functions as a cofactor of DNA polymerase-primase complex
    Title: NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13936, FLJ25416, FLJ38838

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA damage-induced apoptosis suppressor protein
Names
nitric oxide-inducible gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363481.2 → NP_001350410.1  DNA damage-induced apoptosis suppressor protein

    Status: VALIDATED

    Source sequence(s)
    AP001646
    Consensus CDS
    CCDS8263.1
    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856
    UniProtKB/TrEMBL
    A8K8N4
    Related
    ENSP00000329930.4, ENST00000329143.4
    Conserved Domains (1) summary
    cl09930
    Location:8 → 130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  2. NM_145018.4 → NP_659455.3  DNA damage-induced apoptosis suppressor protein

    See identical proteins and their annotated locations for NP_659455.3

    Status: VALIDATED

    Source sequence(s)
    AA477171, AK096157, BC039268, DB023053, DB454086
    Consensus CDS
    CCDS8263.1
    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856
    UniProtKB/TrEMBL
    A8K8N4
    Related
    ENSP00000435421.1, ENST00000533655.6
    Conserved Domains (1) summary
    cl09930
    Location:8 → 130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    82901736..82934659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448400.2 → XP_024304168.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856
    UniProtKB/TrEMBL
    A8K8N4
    Conserved Domains (1) summary
    cl09930
    Location:8 → 130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  2. XM_011544836.3 → XP_011543138.1  DNA damage-induced apoptosis suppressor protein isoform X1

    See identical proteins and their annotated locations for XP_011543138.1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856
    UniProtKB/TrEMBL
    A8K8N4
    Conserved Domains (1) summary
    cl09930
    Location:8 → 130
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  3. XM_011544837.2 → XP_011543139.1  DNA damage-induced apoptosis suppressor protein isoform X2

    See identical proteins and their annotated locations for XP_011543139.1

    UniProtKB/TrEMBL
    B4DMA1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    82825989..82871120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368021.1 → XP_054223996.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856

  2. XM_054368019.1 → XP_054223994.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856

  3. XM_054368022.1 → XP_054223997.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856

  4. XM_054368020.1 → XP_054223995.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856

  5. XM_054368023.1 → XP_054223998.1  DNA damage-induced apoptosis suppressor protein isoform X1

    UniProtKB/Swiss-Prot
    Q8IXT1, Q96LK6, Q9H856

  6. XM_054368024.1 → XP_054223999.1  DNA damage-induced apoptosis suppressor protein isoform X2

    UniProtKB/TrEMBL
    B4DMA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXT1.2 GenPept UniProtKB/Swiss-Prot:Q8IXT1

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