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RBM24 RNA binding motif protein 24 [ Homo sapiens (human) ]

Gene ID: 221662, updated on 27-Nov-2024

Summary

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Official Symbol
RBM24provided by HGNC
Official Full Name
RNA binding motif protein 24provided by HGNC
Primary source
HGNC:HGNC:21539
See related
Ensembl:ENSG00000112183 MIM:617603; AllianceGenome:HGNC:21539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNPC6; dJ259A10.1
Summary
Enables mRNA 3'-UTR AU-rich region binding activity; mRNA CDS binding activity; and sequence-specific mRNA binding activity. Involved in several processes, including negative regulation of cytoplasmic translation; positive regulation of cell differentiation; and regulation of mRNA metabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart (RPKM 42.8), endometrium (RPKM 14.9) and 4 other tissues See more
Orthologs
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Genomic context

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See RBM24 in Genome Data Viewer
Location:
6p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (17281361..17293871)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (17153424..17165937)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (17281592..17294102)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901269 Neighboring gene uncharacterized LOC101928463 Neighboring gene stathmin domain containing 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:17179073-17180272 Neighboring gene MPRA-validated peak5698 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:17311541-17312740 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:17341060-17342259 Neighboring gene Sharpr-MPRA regulatory region 1209 Neighboring gene ESD pseudogene 1 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 Neighboring gene uncharacterized LOC101928491

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untranslated region. Yao Y, et al. Antiviral Res, 2023 Jan. PMID 36464077, Free PMC Article
  2. Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner. Lu SH, et al. Circ Res, 2022 Jan 7. PMID 34816743
  3. Rbm24 modulates neuronal RNA splicing to restrict cognitive dysfunction. Yao D, et al. Int J Biol Macromol, 2024 Sep. PMID 39004256
  4. RNA binding protein 24 regulates the translation and replication of hepatitis C virus. Cao H, et al. Protein Cell, 2018 Nov. PMID 29380205, Free PMC Article
  5. RNA-Binding Motif Protein 24 (RBM24) Is Involved in Pregenomic RNA Packaging by Mediating Interaction between Hepatitis B Virus Polymerase and the Epsilon Element. Yao Y, et al. J Virol, 2019 Mar 15. PMID 30626666, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the beta-catenin pathway.
    Title: YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the β-catenin pathway.
  2. Rbm24 modulates neuronal RNA splicing to restrict cognitive dysfunction.
    Title: Rbm24 modulates neuronal RNA splicing to restrict cognitive dysfunction.
  3. MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral hemorrhage.
    Title: MiR-20a-5p targets RBM24 and alleviates hypertensive intracerebral hemorrhage.
  4. RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untranslated region.
    Title: RBM24 inhibits the translation of SARS-CoV-2 polyproteins by targeting the 5'-untranslated region.
  5. RBM24 controls cardiac QT interval through CaMKIIdelta splicing.
    Title: RBM24 controls cardiac QT interval through CaMKIIδ splicing.
  6. RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.
    Title: RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop.
  7. Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.
    Title: Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.
  8. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
    Title: RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA.
  9. TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659.
    Title: TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659.
  10. TRIM56 suppresses the malignant development of hepatocellular carcinoma via targeting RBM24 and inactivating the Wnt signaling.
    Title: TRIM56 suppresses the malignant development of hepatocellular carcinoma via targeting RBM24 and inactivating the Wnt signaling.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26355, FLJ30829, FLJ37697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA CDS binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA intronic binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocardial cushion development IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of myotube differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of skeletal muscle fiber differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 24
Names
RNA-binding region (RNP1, RRM) containing 6
RNA-binding region-containing protein 6

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143941.1 → NP_001137413.1  RNA-binding protein 24 isoform 3

    See identical proteins and their annotated locations for NP_001137413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK055391, AL136305, BC040928, BP309176
    Consensus CDS
    CCDS47379.1
    UniProtKB/TrEMBL
    H0Y8S7
    Related
    ENSP00000396898.2, ENST00000425446.6
    Conserved Domains (1) summary
    cl17169
    Location:1 → 28
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001143942.2 → NP_001137414.1  RNA-binding protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001137414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK315856, AL136305, BC040928
    Consensus CDS
    CCDS47378.1
    UniProtKB/Swiss-Prot
    E9PAY4, Q6QDA4, Q8N9D3, Q96NI3, Q9BX46
    UniProtKB/TrEMBL
    A8KAI7, H0Y8S7
    Related
    ENSP00000368341.5, ENST00000379052.10
    Conserved Domains (1) summary
    cd12384
    Location:11 → 86
    RRM_RBM24_RBM38_like; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins

  3. NM_153020.2 → NP_694565.1  RNA-binding protein 24 isoform 2

    See identical proteins and their annotated locations for NP_694565.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK055391, AL136305, BC040928
    Consensus CDS
    CCDS4538.1
    UniProtKB/TrEMBL
    H0Y8S7
    Related
    ENSP00000319551.5, ENST00000318204.5
    Conserved Domains (1) summary
    cl17169
    Location:12 → 41
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    17281361..17293871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514387.3 → XP_011512689.2  RNA-binding protein 24 isoform X1

  2. XM_011514388.3 → XP_011512690.1  RNA-binding protein 24 isoform X2

    See identical proteins and their annotated locations for XP_011512690.1

    UniProtKB/TrEMBL
    B7Z6B7

  3. XM_047418369.1 → XP_047274325.1  RNA-binding protein 24 isoform X3

    UniProtKB/TrEMBL
    B7Z6B4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    17153424..17165937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354627.1 → XP_054210602.1  RNA-binding protein 24 isoform X1

  2. XM_054354628.1 → XP_054210603.1  RNA-binding protein 24 isoform X2

    UniProtKB/TrEMBL
    B7Z6B7

  3. XM_054354629.1 → XP_054210604.1  RNA-binding protein 24 isoform X3

    UniProtKB/TrEMBL
    B7Z6B4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BX46.1 GenPept UniProtKB/Swiss-Prot:Q9BX46

Gene LinkOut

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