U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 [ Mus musculus (house mouse) ]

Gene ID: 22238, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Ugt2b5provided by MGI
Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide B5provided by MGI
Primary source
MGI:MGI:98900
See related
Ensembl:ENSMUSG00000054630 AllianceGenome:MGI:98900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M-1; Udpgt-3; Ugt2b17; Udpgt2b5
Summary
Predicted to enable glucuronosyltransferase activity. Predicted to act upstream of or within steroid metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human UGT2B15 (UDP glucuronosyltransferase family 2 member B15) and UGT2B17 (UDP glucuronosyltransferase family 2 member B17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 72.2) and liver E18 (RPKM 20.2) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ugt2b5 in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87272805..87288199, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87124946..87140340, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B36 Neighboring gene predicted gene, 31230 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B36 pseudogene Neighboring gene predicted gene, 19418

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation. Kimura T, et al. Eur J Biochem, 1987 Nov 2. PMID 3117546
  2. The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. Burchell B, et al. DNA Cell Biol, 1991 Sep. PMID 1909870
  3. Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5. Krasnewich D, et al. Somat Cell Mol Genet, 1987 Mar. PMID 3105095
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in estrogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic glucuronidation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UDP-glucuronosyltransferase 2B17
Names
UDP-glucuronosyltransferase 2 family, member 5
UDP-glucuronosyltransferase 2B5
NP_033493.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009467.3 → NP_033493.3  UDP-glucuronosyltransferase 2B17 precursor

    See identical proteins and their annotated locations for NP_033493.3

    Status: VALIDATED

    Source sequence(s)
    AI118071, AK136480
    Consensus CDS
    CCDS19385.3
    UniProtKB/Swiss-Prot
    P17717
    UniProtKB/TrEMBL
    Q8K169
    Related
    ENSMUSP00000068282.7, ENSMUST00000067790.7
    Conserved Domains (2) summary
    PHA03392
    Location:8 → 489
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24 → 527
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    87272805..87288199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17717.1 GenPept UniProtKB/Swiss-Prot:P17717

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools