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Mcat malonyl CoA:ACP acyltransferase (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 223722, updated on 8-Sep-2024

Summary

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Official Symbol
Mcatprovided by MGI
Official Full Name
malonyl CoA:ACP acyltransferase (mitochondrial)provided by MGI
Primary source
MGI:MGI:2388651
See related
Ensembl:ENSMUSG00000048755 AllianceGenome:MGI:2388651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable [acyl-carrier-protein] S-malonyltransferase activity. Predicted to be involved in fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.5), testis adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 39.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83430998..83439936, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83546797..83555759, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase-like 1 Neighboring gene BCL2-interacting killer Neighboring gene predicted gene, 46495 Neighboring gene translocator protein Neighboring gene tubulin tyrosine ligase-like family, member 12 Neighboring gene STARR-positive B cell enhancer ABC_E8602 Neighboring gene predicted gene, 52182

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency. Webb BD, et al. Elife, 2023 Mar 7. PMID 36881526, Free PMC Article
  2. Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy. Li H, et al. Hum Mol Genet, 2020 Feb 1. PMID 31915829
  3. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. Smith S, et al. PLoS One, 2012. PMID 23077570, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency.
    Title: Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency.
  2. Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.
    Title: Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Names
MCT
[Acyl-carrier-protein] malonyltransferase
mitochondrial malonyltransferase
NP_001025185.1
NP_001402935.1
NP_001402936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030014.3 → NP_001025185.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001025185.1

    Status: VALIDATED

    Source sequence(s)
    AL583889
    Consensus CDS
    CCDS27704.1
    UniProtKB/Swiss-Prot
    Q4FZH0, Q8R3F5
    Related
    ENSMUSP00000051569.9, ENSMUST00000061882.10
    Conserved Domains (1) summary
    cl08282
    Location:16 → 357
    Acyl_transf_1; Acyl transferase domain

  2. NM_001416006.1 → NP_001402935.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL583889

  3. NM_001416007.1 → NP_001402936.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL583889

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83430998..83439936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3F5.3 GenPept UniProtKB/Swiss-Prot:Q8R3F5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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