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Mib1 MIB E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 225164, updated on 9-Dec-2024

Summary

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Official Symbol
Mib1provided by MGI
Official Full Name
MIB E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:2443157
See related
Ensembl:ENSMUSG00000024294 AllianceGenome:MGI:2443157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mib; DIP-1; mindbomb; E430019M12Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including Notch signaling pathway; chordate embryonic development; and circulatory system development. Located in cytoplasmic vesicle. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.8), frontal lobe adult (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mib1 in Genome Data Viewer
Location:
18 A1; 18 5.35 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10725523..10822969)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10725625..10818578)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3 Neighboring gene RIKEN cDNA 4930563E18 gene Neighboring gene predicted gene, 25116 Neighboring gene Mir133a-1, Mir1b and Mir1a-2 host gene Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1a-2 Neighboring gene microRNA 1b Neighboring gene STARR-seq mESC enhancer starr_43802 Neighboring gene STARR-seq mESC enhancer starr_43806 Neighboring gene apurinic/apyrimidinic endonuclease 1 pseudogene Neighboring gene predicted gene, 35814 Neighboring gene PHD finger protein 14 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation. Jeong HW, et al. PLoS One, 2012. PMID 22558446, Free PMC Article
  2. Altered response of pendrin-positive intercalated cells in the kidney of Hoxb7-Cre;Mib1f/f mice. Nam SA, et al. Histol Histopathol, 2015 Jun. PMID 25594189
  3. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Pardo-Saganta A, et al. Cell Stem Cell, 2015 Feb 5. PMID 25658372, Free PMC Article
  4. Targeted disruption of Mib2 causes exencephaly with a variable penetrance. Wu JI, et al. Genesis, 2007 Nov. PMID 17987667
  5. Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells. Yoon KJ, et al. Neuron, 2008 May 22. PMID 18498734

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.
    Title: Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.
  2. Mib1 is necessary for the Notch activation in adjacent retinal progenitor cell (RPC)The retinal pigment epithelium (RPE) expresses active Notch ligands for adjacent RPC
    Title: The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
  3. Deletion of Mib1 resulted in an increase in the fraction of pendrin positive intercalated cells in the kidney.
    Title: Altered response of pendrin-positive intercalated cells in the kidney of Hoxb7-Cre;Mib1f/f mice.
  4. Loss of MIB1 and dismantling of the apical secretory apparatus was the earliest quantifiable aberration in zymogenic cells undergoing transition to a precancerous metaplastic state in mouse.
    Title: The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.
  5. These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus.
    Title: Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.
  6. Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord
    Title: The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.
  7. In contrast to delta-like 1 (Dll1) protein, delta-like 4 (deltall4) function relies on a combination of factors, including strong Mindbomb1 (Mib1) association, ubiquitination, and internalization and recycling back to the cell surface, to engage Notch1 effectively.
    Title: Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
  8. Mib1 in dendritic cells is critical for the activation of Notch signaling in CD4(+) T cells
    Title: Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation.
  9. Data show that Mind bomb 1 (Mib1) is required for correct proximodistal (P-D) patterning of the developing pancreas and beta-cell formation.
    Title: Mind bomb 1 is required for pancreatic β-cell formation.
  10. show that exogenously expressed Mib1 could partially rescue the phenotypes associated with miR-137 overexpression.
    Title: MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1323, MGC18948

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MIB1
Names
DAPK-interacting protein-1
RING-type E3 ubiquitin transferase MIB1
mind bomb homolog 1
mindbomb E3 ubiquitin protein ligase 1
mindbomb homolog 1
skeletrophin
NP_001351926.1
NP_659109.2
XP_006525874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364997.1 → NP_001351926.1  E3 ubiquitin-protein ligase MIB1

    Status: VALIDATED

    Source sequence(s)
    AC105947, AC140316
    Consensus CDS
    CCDS29058.1
    UniProtKB/Swiss-Prot
    Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
    UniProtKB/TrEMBL
    A2RRJ6
    Conserved Domains (9) summary
    PHA03095
    Location:439 → 710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83 → 127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562 → 593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818 → 854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865 → 901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:962 → 1003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154 → 218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670 → 770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333 → 397
    SH3_15; Mind bomb SH3 repeat domain

  2. NM_144860.3 → NP_659109.2  E3 ubiquitin-protein ligase MIB1

    See identical proteins and their annotated locations for NP_659109.2

    Status: VALIDATED

    Source sequence(s)
    AC140316, AY245539
    Consensus CDS
    CCDS29058.1
    UniProtKB/Swiss-Prot
    Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
    UniProtKB/TrEMBL
    A2RRJ6
    Related
    ENSMUSP00000054428.5, ENSMUST00000052838.11
    Conserved Domains (9) summary
    PHA03095
    Location:439 → 710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83 → 127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562 → 593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818 → 854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865 → 901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:962 → 1003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154 → 218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670 → 770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333 → 397
    SH3_15; Mind bomb SH3 repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    10725523..10822969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525811.5 → XP_006525874.1  E3 ubiquitin-protein ligase MIB1 isoform X1

    See identical proteins and their annotated locations for XP_006525874.1

    UniProtKB/Swiss-Prot
    Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q80SY4, Q8BNR1, Q8C6W2, Q921Q1
    UniProtKB/TrEMBL
    A2RRJ6
    Conserved Domains (9) summary
    PHA03095
    Location:439 → 710
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:83 → 127
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:562 → 593
    ANK; ANK repeat [structural motif]
    cd16724
    Location:818 → 854
    RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16725
    Location:865 → 901
    RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    cd16727
    Location:962 → 1003
    RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
    pfam06701
    Location:154 → 218
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:670 → 770
    Ank_2; Ankyrin repeats (3 copies)
    pfam18346
    Location:333 → 397
    SH3_15; Mind bomb SH3 repeat domain

RNA

  1. XR_004939841.1 RNA Sequence

  2. XR_004939840.1 RNA Sequence

  3. XR_004939842.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SY4.1 GenPept UniProtKB/Swiss-Prot:Q80SY4

Gene LinkOut

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