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Wbp1l WW domain binding protein 1 like [ Mus musculus (house mouse) ]

Gene ID: 226178, updated on 2-Nov-2024

Summary

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Official Symbol
Wbp1lprovided by MGI
Official Full Name
WW domain binding protein 1 likeprovided by MGI
Primary source
MGI:MGI:107577
See related
Ensembl:ENSMUSG00000047731 AllianceGenome:MGI:107577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opal1; D19Wsu162e
Summary
Enables ubiquitin protein ligase binding activity. Acts upstream of or within CXCL12-activated CXCR4 signaling pathway; hemopoiesis; and positive regulation of protein ubiquitination. Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Orthologous to human WBP1L (WW domain binding protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 63.4), liver adult (RPKM 60.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wbp1l in Genome Data Viewer
Location:
19 C3; 19 38.97 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46587545..46645828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46599106..46657389)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E8752 Neighboring gene STARR-positive B cell enhancer mm9_chr19:46647489-46647790 Neighboring gene sideroflexin 2 Neighboring gene STARR-positive B cell enhancer ABC_E319 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46728226-46728566 Neighboring gene predicted gene, 36602 Neighboring gene Cyp17a1 promoter Neighboring gene cytochrome P450, family 17, subfamily a, polypeptide 1 Neighboring gene predicted gene, 41857

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. Borna S, et al. J Cell Mol Med, 2020 Jan. PMID 31845480, Free PMC Article
  2. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
  3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.
    Title: Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31104

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CXCL12-activated CXCR4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WW domain binding protein 1-like
Names
outcome predictor in acute leukemia 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177812.1 → NP_001171283.1  WW domain binding protein 1-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001171283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC156982, BC064096
    Consensus CDS
    CCDS50456.1
    UniProtKB/Swiss-Prot
    Q8BGW2
    Related
    ENSMUSP00000096975.5, ENSMUST00000099376.11
    Conserved Domains (1) summary
    pfam11669
    Location:59 → 160
    WBP-1; WW domain-binding protein 1

  2. NM_001177813.1 → NP_001171284.1  WW domain binding protein 1-like isoform 3

    See identical proteins and their annotated locations for NP_001171284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (3) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK142695, BC058949, BC064096
    Consensus CDS
    CCDS50457.1
    UniProtKB/Swiss-Prot
    Q3TF48, Q3U3M2, Q6PD43, Q8BGW2, Q8R0W8
    Related
    ENSMUSP00000107486.5, ENSMUST00000111855.5
    Conserved Domains (1) summary
    pfam11669
    Location:22 → 123
    WBP-1; WW domain-binding protein 1

  3. NM_146099.3 → NP_666211.3  WW domain binding protein 1-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC156982, BC058949, BC064096, BY208074
    Consensus CDS
    CCDS29881.2
    UniProtKB/Swiss-Prot
    Q8BGW2
    Related
    ENSMUSP00000117929.3, ENSMUST00000138302.9
    Conserved Domains (1) summary
    pfam11669
    Location:43 → 144
    WBP-1; WW domain-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46587545..46645828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGW2.1 GenPept UniProtKB/Swiss-Prot:Q8BGW2

Gene LinkOut

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