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Kansl3 KAT8 regulatory NSL complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 226976, updated on 2-Nov-2024

Summary

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Official Symbol
Kansl3provided by MGI
Official Full Name
KAT8 regulatory NSL complex subunit 3provided by MGI
Primary source
MGI:MGI:1918055
See related
Ensembl:ENSMUSG00000010453 AllianceGenome:MGI:1918055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1310; mKIAA1310; 4932435K23; 4632411B12Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of mitochondrial transcription. Part of NSL complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 8-cell stage embryo; blastocyst; and brain. Orthologous to human KANSL3 (KAT8 regulatory NSL complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 24.1), adrenal adult (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kansl3 in Genome Data Viewer
Location:
1 B; 1 15.22 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36374811..36408276, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36335730..36369193, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3268 Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene microRNA 6898 Neighboring gene fer-1 like family member 5 Neighboring gene lectin, mannose-binding 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36501343-36501452 Neighboring gene STARR-positive B cell enhancer ABC_E5746 Neighboring gene predicted gene, 33401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of KANSL3 leads to defective inner cell mass and early embryonic lethality. Chander A, et al. Mol Reprod Dev, 2024 May. PMID 38769918, Free PMC Article
  2. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Karoutas A, et al. Nat Cell Biol, 2019 Oct. PMID 31576060
  3. Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Sheikh BN, et al. Nat Cell Biol, 2020 Jul. PMID 32541879
  4. MOF-associated complexes ensure stem cell identity and Xist repression. Chelmicki T, et al. Elife, 2014 May 19. PMID 24842875, Free PMC Article
  5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
  
part_of NSL complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
KAT8 regulatory NSL complex subunit 3
Names
NSL complex protein NSL3
non-specific lethal 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310513.1 → NP_001297442.1  KAT8 regulatory NSL complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001297442.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030079, AK129329, BC132293
    Consensus CDS
    CCDS78561.1
    UniProtKB/Swiss-Prot
    A2RSY1, Q6ZPU0, Q8C0P9
    Related
    ENSMUSP00000140597.2, ENSMUST00000186470.2
    Conserved Domains (1) summary
    pfam12695
    Location:342 → 436
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_172652.3 → NP_766240.1  KAT8 regulatory NSL complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_766240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC132456
    Consensus CDS
    CCDS14877.1
    UniProtKB/Swiss-Prot
    A2RSY1
    Related
    ENSMUSP00000010597.4, ENSMUST00000010597.10
    Conserved Domains (1) summary
    pfam12695
    Location:342 → 436
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36374811..36408276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320240.3 → XP_017175729.1  KAT8 regulatory NSL complex subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam12695
    Location:243 → 337
    Abhydrolase_5; Alpha/beta hydrolase family

  2. XM_017320236.3 → XP_017175725.1  KAT8 regulatory NSL complex subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam12695
    Location:243 → 337
    Abhydrolase_5; Alpha/beta hydrolase family

  3. XM_036164306.1 → XP_036020199.1  KAT8 regulatory NSL complex subunit 3 isoform X3

    Related
    ENSMUSP00000140547.2, ENSMUST00000185912.7

  4. XM_011238482.3 → XP_011236784.1  KAT8 regulatory NSL complex subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam12695
    Location:243 → 337
    Abhydrolase_5; Alpha/beta hydrolase family

  5. XM_030253628.2 → XP_030109488.1  KAT8 regulatory NSL complex subunit 3 isoform X4

  6. XM_017320242.2 → XP_017175731.1  KAT8 regulatory NSL complex subunit 3 isoform X4

  7. XM_006495902.4 → XP_006495965.1  KAT8 regulatory NSL complex subunit 3 isoform X1

    Conserved Domains (1) summary
    pfam12695
    Location:342 → 436
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RSY1.1 GenPept UniProtKB/Swiss-Prot:A2RSY1

Gene LinkOut

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