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Zfp39 zinc finger protein 39 [ Mus musculus (house mouse) ]

Gene ID: 22698, updated on 12-May-2024

Summary

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Official Symbol
Zfp39provided by MGI
Official Full Name
zinc finger protein 39provided by MGI
Primary source
MGI:MGI:99183
See related
Ensembl:ENSMUSG00000037001 AllianceGenome:MGI:99183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp-39; CTfin33
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and trunk somite. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 13.6), liver E14 (RPKM 3.6) and 17 other tissues See more
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Genomic context

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See Zfp39 in Genome Data Viewer
Location:
11 B1.3; 11 36.35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58778979..58795051, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58888153..58904225, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E588 Neighboring gene olfactory receptor family 9 subfamily E member 1 Neighboring gene predicted gene 12258 Neighboring gene RIKEN cDNA 2810021J22 gene Neighboring gene STARR-positive B cell enhancer ABC_E9824 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58697199-58697308 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:58697335-58697545 Neighboring gene STARR-positive B cell enhancer ABC_E2990 Neighboring gene predicted gene 12257 Neighboring gene butyrophilin-like 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce T, et al. Dev Biol, 1992 Oct. PMID 1397691
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011758.2 → NP_035888.2  zinc finger protein 39

    See identical proteins and their annotated locations for NP_035888.2

    Status: VALIDATED

    Source sequence(s)
    AK045944, AK141135
    Consensus CDS
    CCDS24752.1
    UniProtKB/Swiss-Prot
    Q02525, Q2YDX7, Q5NC60, Q8BL91
    Related
    ENSMUSP00000099764.2, ENSMUST00000102703.2
    Conserved Domains (6) summary
    smart00349
    Location:59 → 118
    KRAB; krueppel associated box
    COG5048
    Location:407 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:355 → 374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:59 → 98
    KRAB; KRAB box
    pfam13465
    Location:535 → 560
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58778979..58795051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02525.2 GenPept UniProtKB/Swiss-Prot:Q02525

Gene LinkOut

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