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FHL2 four and a half LIM domains 2 [ Homo sapiens (human) ]

Gene ID: 2274, updated on 3-Nov-2024

Summary

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Official Symbol
FHL2provided by HGNC
Official Full Name
four and a half LIM domains 2provided by HGNC
Primary source
HGNC:HGNC:3703
See related
Ensembl:ENSG00000115641 MIM:602633; AllianceGenome:HGNC:3703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAL; AAG11; FHL-2; SLIM3; SLIM-3
Summary
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
Expression
Biased expression in heart (RPKM 149.2), ovary (RPKM 139.8) and 13 other tissues See more
Orthologs
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Genomic context

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See FHL2 in Genome Data Viewer
Location:
2q12.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (105357712..105438529, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105818881..105899699, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105974169..106054986, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:105866724-105867602 Neighboring gene transforming growth factor beta receptor associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16313 Neighboring gene Sharpr-MPRA regulatory region 6730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16315 Neighboring gene C2orf49 divergent transcript Neighboring gene chromosome 2 open reading frame 49 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105985867-105986368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105986369-105986868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:106015289-106016111 Neighboring gene NANOG hESC enhancer GRCh37_chr2:106043866-106044367 Neighboring gene uncharacterized LOC105373529 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:106093757-106093969 Neighboring gene VISTA enhancer hs2590 Neighboring gene uncharacterized LOC105375311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel colon cancer gene therapy using rAAV‑mediated expression of human shRNA-FHL2. Wu Y, et al. Int J Oncol, 2013 Nov. PMID 24008552
  2. Four and a half LIM domain protein 2 enhances differentiation and mineralization of human dental pulp cells. Tian X, et al. J Endod, 2015 Apr. PMID 25662359
  3. Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study. Gabriel B, et al. J Soc Gynecol Investig, 2006 Jan. PMID 16378916
  4. Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer. Al-Nomani L, et al. Pathol Res Pract, 2015 Feb. PMID 25554651
  5. How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease. Habibe JJ, et al. Cells, 2021 Oct 1. PMID 34685595, Free PMC Article

See all (230) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.
    Title: Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.
  2. FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.
    Title: FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.
  3. Downregulation of FHL2 suppressed trophoblast migration, invasion and epithelial-mesenchymal transition in recurrent miscarriage.
    Title: Downregulation of FHL2 suppressed trophoblast migration, invasion and epithelial-mesenchymal transition in recurrent miscarriage.
  4. FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta Expression through Regulating IRF-3.
    Title: FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
  5. The roles of FHL2 in cancer.
    Title: The roles of FHL2 in cancer.
  6. FHL2 Genetic Polymorphisms and Pro-Diabetogenic Lipid Profile in the Multiethnic HELIUS Cohort.
    Title: FHL2 Genetic Polymorphisms and Pro-Diabetogenic Lipid Profile in the Multiethnic HELIUS Cohort.
  7. High FHL2 mRNA expression and its prognostic value in lung cancer.
    Title: High FHL2 mRNA expression and its prognostic value in lung cancer.
  8. High level of FHL2 exacerbates the outcome of non-small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells.
    Title: High level of FHL2 exacerbates the outcome of non-small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells.
  9. c-Abl kinase regulates cell proliferation and ionizing radiation-induced G2/M arrest via phosphorylation of FHL2.
    Title: c-Abl kinase regulates cell proliferation and ionizing radiation-induced G2/M arrest via phosphorylation of FHL2.
  10. How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.
    Title: How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.
Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bHLH transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in atrial cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in heart trabecula formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hormone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventricular cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
four and a half LIM domains protein 2
Names
LIM domain protein DRAL
aging-associated gene 11
down-regulated in rhabdomyosarcoma LIM protein
skeletal muscle LIM-protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008844.2 RefSeqGene

    Range
    5261..82948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_740

mRNA and Protein(s)

  1. NM_001039492.3 → NP_001034581.1  four and a half LIM domains protein 2 isoform a

    See identical proteins and their annotated locations for NP_001034581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AC012360, AC108058, DQ266432, L42176
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000322909.8, ENST00000322142.13
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001318894.1 → NP_001305823.1  four and a half LIM domains protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AC108058, CR936682, DQ266432
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000386892.3, ENST00000409177.6
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001318895.3 → NP_001305824.1  four and a half LIM domains protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AC108058, DQ266432
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000433567.2, ENST00000530340.6
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_001318896.2 → NP_001305825.1  four and a half LIM domains protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AC012360, AL521653, DA682076, DQ266432
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000386633.1, ENST00000408995.5
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  5. NM_001318897.2 → NP_001305826.1  four and a half LIM domains protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate exon compared to variant 2. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 9 and 10 both encode the same isoform (b).
    Source sequence(s)
    AB158503, AC012360, BP257466, DQ266432
    UniProtKB/TrEMBL
    Q53T40
    Conserved Domains (3) summary
    cd09431
    Location:48 → 104
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:107 → 164
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:1 → 43
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  6. NM_001318898.2 → NP_001305827.1  four and a half LIM domains protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks two alternate exons compared to variant 2. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 9 and 10 both encode the same isoform (b).
    Source sequence(s)
    AC012360, BI562043, DQ266432
    UniProtKB/TrEMBL
    Q53T40
    Conserved Domains (3) summary
    cd09431
    Location:48 → 104
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:107 → 164
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:1 → 43
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  7. NM_001318899.2 → NP_001305828.1  four and a half LIM domains protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and contains an alternate internal exon compared to variant 2. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC012360, AC108058, BM559077, DA682076, DQ266432
    UniProtKB/TrEMBL
    Q53T40
    Conserved Domains (3) summary
    cd09431
    Location:54 → 110
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:113 → 170
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:1 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  8. NM_001374399.1 → NP_001361328.1  four and a half LIM domains protein 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AC012360, AC068273, AC108058
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000386665.1, ENST00000409807.5
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  9. NM_001450.4 → NP_001441.4  four and a half LIM domains protein 2 isoform a

    See identical proteins and their annotated locations for NP_001441.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    AA758053, AC012360, BC014397, L42176
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000377021.3, ENST00000393353.7
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  10. NM_201555.3 → NP_963849.1  four and a half LIM domains protein 2 isoform a

    See identical proteins and their annotated locations for NP_963849.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform a. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform.
    Source sequence(s)
    BC014397, L42176
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000344266.5, ENST00000344213.9
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  11. NM_201557.5 → NP_963851.2  four and a half LIM domains protein 2 isoform a

    See identical proteins and their annotated locations for NP_963851.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
    Source sequence(s)
    BP257466, DQ266432, U29332
    Consensus CDS
    CCDS2070.1
    UniProtKB/Swiss-Prot
    Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
    UniProtKB/TrEMBL
    D3DVK0, Q2TSB7, Q561W1, Q6I9R8
    Related
    ENSP00000377020.3, ENST00000393352.7
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    105357712..105438529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    105818881..105899699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201556.1: Suppressed sequence

    Description
    NM_201556.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14192.3 GenPept UniProtKB/Swiss-Prot:Q14192

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