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Camsap1 calmodulin regulated spectrin-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 227634, updated on 17-Aug-2024

Summary

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Official Symbol
Camsap1provided by MGI
Official Full Name
calmodulin regulated spectrin-associated protein 1provided by MGI
Primary source
MGI:MGI:3036242
See related
Ensembl:ENSMUSG00000026933 AllianceGenome:MGI:3036242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRO2405; 9530003A05Rik
Summary
Predicted to enable calmodulin binding activity; microtubule minus-end binding activity; and spectrin binding activity. Predicted to be involved in several processes, including cytoplasmic microtubule organization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in microtubule. Predicted to colocalize with microtubule minus-end. Is expressed in brain; cerebral cortex; and hippocampus. Orthologous to human CAMSAP1 (calmodulin regulated spectrin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 21.8), CNS E14 (RPKM 10.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 18.29 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25816850..25873574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25926838..25983562, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene potassium channel, subfamily T, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene STARR-positive B cell enhancer ABC_E3363 Neighboring gene ubiquitin associated domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The astrocytic lineage marker calmodulin-regulated spectrin-associated protein 1 (Camsap1): phenotypic heterogeneity of newly born Camsap1-expressing cells in injured mouse brain. Yoshioka N, et al. J Comp Neurol, 2012 Apr 15. PMID 22095662
  2. Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder. Khalaf-Nazzal R, et al. Am J Hum Genet, 2022 Nov 3. PMID 36283405, Free PMC Article
  3. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells. Coquand L, et al. J Cell Biol, 2021 Aug 2. PMID 34019079, Free PMC Article
  4. A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1). Yamamoto M, et al. J Neurosci Res, 2009 Feb. PMID 18756519
  5. Wdr47, Camsaps, and Katanin cooperate to generate ciliary central microtubules. Liu H, et al. Nat Commun, 2021 Oct 4. PMID 34608154, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircCamsap1 is dispensable for male fertility in mice.
    Title: CircCamsap1 is dispensable for male fertility in mice.
  2. Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder.
    Title: Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder.
  3. CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
    Title: CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
  4. Camsap1-expressing cells exhibit regional heterogeneity in an early phase after stab injury of mouse brain. Newly born reactive astrocytes are derived from heterogeneous Camsap1-expressing cells in the injured brain.
    Title: The astrocytic lineage marker calmodulin-regulated spectrin-associated protein 1 (Camsap1): phenotypic heterogeneity of newly born Camsap1-expressing cells in injured mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule minus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule minus-end ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calmodulin-regulated spectrin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276359.2 → NP_001263288.1  calmodulin-regulated spectrin-associated protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL731682
    Consensus CDS
    CCDS50538.2
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    UniProtKB/TrEMBL
    A0A0A0MQE5
    Related
    ENSMUSP00000109804.3, ENSMUST00000114167.9
    Conserved Domains (4) summary
    pfam15346
    Location:1257 → 1334
    ARGLU; Arginine and glutamate-rich 1
    pfam08683
    Location:1444 → 1562
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:228 → 311
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:859 → 917
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  2. NM_001276360.2 → NP_001263289.1  calmodulin-regulated spectrin-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.
    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    pfam15346
    Location:1268 → 1345
    ARGLU; Arginine and glutamate-rich 1
    pfam08683
    Location:1455 → 1573
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:239 → 322
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:870 → 928
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  3. NM_001276361.2 → NP_001263290.1  calmodulin-regulated spectrin-associated protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is longer compared to isoform 1.
    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    pfam15346
    Location:1277 → 1354
    ARGLU; Arginine and glutamate-rich 1
    pfam08683
    Location:1464 → 1582
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:248 → 331
    CAMSAP_CH; CAMSAP CH domain
    pfam17095
    Location:879 → 937
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  4. NM_001372499.2 → NP_001359428.1  calmodulin-regulated spectrin-associated protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    smart01051
    Location:1455 → 1583
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:239 → 322
    CAMSAP_CH; CAMSAP CH domain
    pfam15346
    Location:1268 → 1345
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:870 → 928
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  5. NM_001408050.1 → NP_001394979.1  calmodulin-regulated spectrin-associated protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3

  6. NM_001408051.1 → NP_001394980.1  calmodulin-regulated spectrin-associated protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3

  7. NM_001408052.1 → NP_001394981.1  calmodulin-regulated spectrin-associated protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3

  8. NM_001408053.1 → NP_001394982.1  calmodulin-regulated spectrin-associated protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3

  9. NM_001408054.1 → NP_001394983.1  calmodulin-regulated spectrin-associated protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL731682
    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3

RNA

  1. NR_176449.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731682

  2. NR_176450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731682

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25816850..25873574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497900.4 → XP_006497963.1  calmodulin-regulated spectrin-associated protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006497963.1

    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    smart01051
    Location:1344 → 1472
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:128 → 211
    CAMSAP_CH; CAMSAP CH domain
    pfam15346
    Location:1157 → 1234
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:759 → 817
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  2. XM_006497899.3 → XP_006497962.1  calmodulin-regulated spectrin-associated protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006497962.1

    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    smart01051
    Location:1344 → 1472
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:128 → 211
    CAMSAP_CH; CAMSAP CH domain
    pfam15346
    Location:1157 → 1234
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:759 → 817
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  3. XM_036160731.1 → XP_036016624.1  calmodulin-regulated spectrin-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    smart01051
    Location:1423 → 1551
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam11971
    Location:207 → 290
    CAMSAP_CH; CAMSAP CH domain
    pfam15346
    Location:1236 → 1313
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:838 → 896
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

  4. XM_036160733.1 → XP_036016626.1  calmodulin-regulated spectrin-associated protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A2AHC3, Q7TQF8, Q8CBV3
    Conserved Domains (4) summary
    pfam11971
    Location:198 → 281
    CAMSAP_CH; CAMSAP CH domain
    pfam08683
    Location:1415 → 1533
    CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
    pfam15346
    Location:1227 → 1304
    ARGLU; Arginine and glutamate-rich 1
    pfam17095
    Location:829 → 887
    CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001115076.1: Suppressed sequence

    Description
    NM_001115076.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AHC3.1 GenPept UniProtKB/Swiss-Prot:A2AHC3

Gene LinkOut

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Chemical Information
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