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Zfy1 zinc finger protein 1, Y-linked [ Mus musculus (house mouse) ]

Gene ID: 22767, updated on 4-Jan-2025

Summary

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Official Symbol
Zfy1provided by MGI
Official Full Name
zinc finger protein 1, Y-linkedprovided by MGI
Primary source
MGI:MGI:99212
See related
Ensembl:ENSMUSG00000053211 AllianceGenome:MGI:99212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfy2; Zfy-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfy1 in Genome Data Viewer
Location:
Y; Ypter
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (725207..797409, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (725207..797409, complement)

Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene predicted gene 29089 Neighboring gene STARR-seq mESC enhancer starr_48292 Neighboring gene STARR-seq mESC enhancer starr_48293 Neighboring gene ubiquitin-activating enzyme E1, Chr Y 1 pseudogene Neighboring gene ubiquitin-activating enzyme, Chr Y Neighboring gene ras homolog A translocated to the Y, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfyl encodes a nuclear sequence-specific DNA binding protein. Taylor-Harris P, et al. FEBS Lett, 1995 Mar 6. PMID 7883055
  2. RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis. Zhang Y, et al. Mamm Genome, 2017 Apr. PMID 28251288
  3. Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Su H, et al. Mol Reprod Dev, 1992 Nov. PMID 1449792
  4. The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers. Mardon G, et al. Cell, 1989 Mar 10. PMID 2493989
  5. Sequence of cDNA for murine Zfy-1, a candidate for Tdy. Ashworth A, et al. Nucleic Acids Res, 1989 Apr 11. PMID 2497440, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
    Title: Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
  2. our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati
    Title: RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.
  3. we show that in mice, Zfy genes(Zfy1 and Zfy2 ) are also necessary for efficient meiotic sex chrand the sex chromosomes are not correctly silenced in Zfy-deficient spermatocytes.
    Title: Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.
  4. Zfy1-KO mice did not show any significant phenotypic alterations. Zfy1/2-DKO mice were infertile and displayed abnormal sperm morphology and fertilization failure.
    Title: Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
  5. genetic information on the short arm of the Y chromosome promotes meiosis II, and by transgene addition Zfy1 and Zfy2 were identified as the genes responsible.
    Title: Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
  6. Studies identified a Zfy2 transcript that predominates in spermatids, and a Zfy1 transcript, lacking an exon encoding approximately half of the acidic domain.
    Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger Y-chromosomal protein 1
Names
Y-linked zinc finger protein 1
Y-linked zinc finger protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009570.4 → NP_033596.3  zinc finger Y-chromosomal protein 1

    See identical proteins and their annotated locations for NP_033596.3

    Status: VALIDATED

    Source sequence(s)
    AK076618, X14382
    Consensus CDS
    CCDS30539.1
    UniProtKB/Swiss-Prot
    E9QKM5, P10925, Q8C638
    Related
    ENSMUSP00000069364.5, ENSMUST00000065545.6
    Conserved Domains (6) summary
    COG5048
    Location:513 → 687
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:528 → 548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:405 → 425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:526 → 548
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:68 → 388
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:540 → 562
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000087.8 Reference GRCm39 C57BL/6J

    Range
    725207..797409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10925.3 GenPept UniProtKB/Swiss-Prot:P10925

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