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ITGA11 integrin subunit alpha 11 [ Homo sapiens (human) ]

Gene ID: 22801, updated on 2-Nov-2024

Summary

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Official Symbol
ITGA11provided by HGNC
Official Full Name
integrin subunit alpha 11provided by HGNC
Primary source
HGNC:HGNC:6136
See related
Ensembl:ENSG00000137809 MIM:604789; AllianceGenome:HGNC:6136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT18964
Summary
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues See more
Orthologs
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Genomic context

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See ITGA11 in Genome Data Viewer
Location:
15q23
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68296532..68432163, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66115251..66255043, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68588870..68724502, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903593 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:68564472-68565671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68570079-68570980 Neighboring gene NANOG hESC enhancer GRCh37_chr15:68577826-68578327 Neighboring gene fem-1 homolog B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68607402-68608268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68609715-68610215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68634197-68634792 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:68657127-68658326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68662273-68662774 Neighboring gene Sharpr-MPRA regulatory region 14581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68722903-68723662 Neighboring gene Sharpr-MPRA regulatory region 1870 Neighboring gene uncharacterized LOC124903513 Neighboring gene uncharacterized LOC105370873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation. Erusappan P, et al. Sci Rep, 2019 Oct 25. PMID 31653900, Free PMC Article
  2. Collagen-binding α11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe. Peavey M, et al. Reprod Sci, 2014 Sep. PMID 24520080, Free PMC Article
  3. Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases. Bansal R, et al. Exp Mol Med, 2017 Nov 17. PMID 29147013, Free PMC Article
  4. The role of Protein Disulfide Isomerase and thiol bonds modifications in activation of integrin subunit alpha11. Popielarski M, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29203246
  5. Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer. Schnittert J, et al. FASEB J, 2019 May. PMID 30808244

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
    Title: PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
  2. Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
    Title: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.
  3. Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin alpha11 expression.
    Title: Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.
  4. Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
    Title: Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
  5. Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11/miR516b5p axis.
    Title: Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.
  6. p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating alpha1 integrin expression.
    Title: p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating α1 integrin expression.
  7. Integrin alpha11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
    Title: Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
  8. integrin alpha11 pro-invasive activity relies on its ability to interact with PDGFRbeta in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a pro-invasive matricellular protein.
    Title: Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.
  9. this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of the differentiation of Pancreatic stellate cells into cancer-associated fibroblasts and paracrine effects.
    Title: Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.
  10. Data show that integrin alpha-11 (integrin alpha11) is a physiologically important receptor for Osteolectin, mediating its effect on osteogenesis.
    Title: Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables collagen binding involved in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle organ development TAS
Traceable Author Statement
more info
 PubMed 
involved_in osteoblast differentiation HDA PubMed 
involved_in substrate-dependent cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alpha11-beta1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
integrin alpha-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046911.1 RefSeqGene

    Range
    4998..140629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004439.2 → NP_001004439.1  integrin alpha-11 precursor

    See identical proteins and their annotated locations for NP_001004439.1

    Status: REVIEWED

    Source sequence(s)
    AC021553, AC100825, AF109681, AF137378, AK095863, AL359064, BX496541, CN358985
    Consensus CDS
    CCDS45291.1
    UniProtKB/Swiss-Prot
    J3KQM2, Q8WYI8, Q9UKQ1, Q9UKX5
    UniProtKB/TrEMBL
    A8K8T0
    Related
    ENSP00000327290.7, ENST00000315757.9
    Conserved Domains (3) summary
    smart00191
    Location:538 → 592
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:163 → 341
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:635 → 1034
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    68296532..68432163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521363.3 → XP_011519665.1  integrin alpha-11 isoform X1

    UniProtKB/TrEMBL
    A8K8T0
    Conserved Domains (3) summary
    smart00191
    Location:469 → 523
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:94 → 272
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:566 → 965
    Integrin_alpha2; Integrin alpha

  2. XM_005254228.4 → XP_005254285.1  integrin alpha-11 isoform X2

    UniProtKB/TrEMBL
    A8K8T0
    Conserved Domains (3) summary
    smart00191
    Location:436 → 490
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:61 → 239
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:533 → 932
    Integrin_alpha2; Integrin alpha

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    66115251..66255043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012211.3: Suppressed sequence

    Description
    NM_012211.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKX5.2 GenPept UniProtKB/Swiss-Prot:Q9UKX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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