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Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 [ Mus musculus (house mouse) ]

Gene ID: 228026, updated on 24-Dec-2024

Summary

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Official Symbol
Pdk1provided by MGI
Official Full Name
pyruvate dehydrogenase kinase, isoenzyme 1provided by MGI
Primary source
MGI:MGI:1926119
See related
Ensembl:ENSMUSG00000006494 AllianceGenome:MGI:1926119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B830012B01; D530020C15Rik
Summary
Predicted to enable ATP binding activity; identical protein binding activity; and protein kinase activity. Involved in regulation of acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Note: Pdk1 (Gene ID: 228026) and Pdpk1 (Gene ID: 18607) share the Pdk1 symbol/alias in common. Pdk1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (Pdpk1), which can be confused with the official symbol for pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1). [03 Apr 2019]
Expression
Ubiquitous expression in heart adult (RPKM 12.2), thymus adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pdk1 in Genome Data Viewer
Location:
2 C3; 2 42.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71703398..71734202)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71873215..71903858)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene integrin alpha 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71652164-71652396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71704749-71704932 Neighboring gene STARR-seq mESC enhancer starr_04811 Neighboring gene predicted gene, 46785 Neighboring gene predicted gene, 39845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. Tan Z, et al. J Immunol, 2015 Jun 15. PMID 25964487, Free PMC Article
  2. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. Gerriets VA, et al. J Clin Invest, 2015 Jan. PMID 25437876, Free PMC Article
  3. Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes. Yao Y, et al. Cell Death Dis, 2023 Nov 7. PMID 37935660, Free PMC Article
  4. Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis. Sun X, et al. Gene, 2024 Aug 5. PMID 38657876
  5. Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease. Ye X, et al. Neuropathol Appl Neurobiol, 2022 Dec. PMID 35881686

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis.
    Title: Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis.
  2. Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
    Title: Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
  3. PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1.
    Title: PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1.
  4. Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
    Title: Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
  5. Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.
    Title: Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6.
  6. Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5xFAD mouse model of Alzheimer's disease.
    Title: Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease.
  7. Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.
    Title: Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.
  8. Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages.
    Title: Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages.
  9. High PDK1 expression promotes breast cancer stemness.
    Title: Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia.
  10. HIF-1alpha-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming.
    Title: HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • D530020C15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in hypoxia-inducible factor-1alpha signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intracellular signal transduction ISA
Inferred from Sequence Alignment
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
  
part_of pyruvate dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial
Names
PDH kinase 1
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
pyruvate dehydrogenase kinase, isozyme 1
NP_001346931.1
NP_766253.2
XP_011237746.1
XP_011237747.1
XP_011237748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360002.1 → NP_001346931.1  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, resulting in a novel 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL928963
    UniProtKB/TrEMBL
    Q8R2U8
    Conserved Domains (2) summary
    smart00387
    Location:192 → 312
    HATPase_c; Histidine kinase-like ATPases
    pfam10436
    Location:1 → 142
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. NM_172665.5 → NP_766253.2  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_766253.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046805, AK153649, AK165090, BE994546
    Consensus CDS
    CCDS16119.1
    UniProtKB/Swiss-Prot
    Q3U5E5, Q8BFP9
    UniProtKB/TrEMBL
    Q8R2U8
    Related
    ENSMUSP00000006669.6, ENSMUST00000006669.6
    Conserved Domains (3) summary
    smart00387
    Location:268 → 388
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:268 → 396
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:56 → 218
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    71703398..71734202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239444.3 → XP_011237746.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q8R2U8
    Conserved Domains (2) summary
    cd16929
    Location:259 → 425
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:56 → 255
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_011239445.4 → XP_011237747.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011237747.1

    UniProtKB/TrEMBL
    Q8R2U8
    Conserved Domains (2) summary
    cd16929
    Location:183 → 349
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:2 → 179
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_011239446.4 → XP_011237748.1  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011237748.1

    UniProtKB/TrEMBL
    Q8R2U8
    Conserved Domains (2) summary
    cd16929
    Location:183 → 349
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:2 → 179
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RNA

  1. XR_003952294.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFP9.2 GenPept UniProtKB/Swiss-Prot:Q8BFP9

Gene LinkOut

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