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ATG14 autophagy related 14 [ Homo sapiens (human) ]

Gene ID: 22863, updated on 10-Dec-2024

Summary

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Official Symbol
ATG14provided by HGNC
Official Full Name
autophagy related 14provided by HGNC
Primary source
HGNC:HGNC:19962
See related
Ensembl:ENSG00000126775 MIM:613515; AllianceGenome:HGNC:19962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG14L; BARKOR; KIAA0831
Summary
Enables GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Involved in several processes, including early endosome to late endosome transport; macroautophagy; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Part of phosphatidylinositol 3-kinase complex, class III. Is active in phagophore assembly site. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ATG14 in Genome Data Viewer
Location:
14q22.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55366391..55411830, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49572142..49617561, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55833109..55878548, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene F-box protein 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:55754571-55754700 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 9702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8430 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8431 Neighboring gene NANOG hESC enhancer GRCh37_chr14:55794909-55795410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8432 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5783 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene TATA-box binding protein like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. Matsunaga K, et al. J Cell Biol, 2010 Aug 23. PMID 20713597, Free PMC Article
  2. Silencing of Barkor/ATG14 sensitizes osteosarcoma cells to cisplatin‑induced apoptosis. Zhao Z, et al. Int J Mol Med, 2014 Feb. PMID 24337183, Free PMC Article
  3. ATG4 promotes cell proliferation, migration and invasion in HCC and predicts a poor prognosis. Zhu XJ, et al. Eur Rev Med Pharmacol Sci, 2020 Dec. PMID 33378015
  4. Streptococcus pneumoniae promotes its own survival via choline-binding protein CbpC-mediated degradation of ATG14. Shizukuishi S, et al. Autophagy, 2020 Aug. PMID 32508214, Free PMC Article
  5. CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis. Zhao Z, et al. Immunol Res, 2022 Jun. PMID 35066780

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
    Title: Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination.
  2. KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
    Title: KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
  3. ATG14 plays a critical role in hepatic lipid droplet homeostasis.
    Title: ATG14 plays a critical role in hepatic lipid droplet homeostasis.
  4. CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
    Title: CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.
  5. ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
    Title: ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis.
  6. Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
    Title: Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway.
  7. HIF-1alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
    Title: HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
  8. SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
    Title: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation.
  9. [miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
    Title: [miR-148b-3p inhibits the proliferation and autophagy of acute myeloid leukemia cells by targeting ATG14].
  10. [MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].
    Title: [MicroRNA-424 inhibits autophagy and proliferation of hepatocellular carcinoma cells by targeting ATG14].
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ATG14 autophagy related 14 homolog (S. cerevisiae, ATG14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0831, MGC126291, MGC126292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol 3-kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagosome membrane docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome membrane docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in early endosome to late endosome transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within endosome to lysosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to lysosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of macroautophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein complex stability IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mitochondrial depolarisation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in extrinsic component of omegasome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of omegasome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagophore assembly site membrane TAS
Traceable Author Statement
more info
  
part_of phosphatidylinositol 3-kinase complex, class III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
beclin 1-associated autophagy-related key regulator
Names
ATG14 autophagy related 14 homolog
Beclin 1-Interacting protein
autophagy-related protein 14-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014924.5 → NP_055739.2  beclin 1-associated autophagy-related key regulator

    See identical proteins and their annotated locations for NP_055739.2

    Status: VALIDATED

    Source sequence(s)
    AA988343, AK131251, AL158801
    Consensus CDS
    CCDS32087.1
    UniProtKB/Swiss-Prot
    A6NJE4, A8K9U5, B7ZWP5, O94920, Q32MK7, Q32MK8, Q6ZNE5
    Related
    ENSP00000247178.5, ENST00000247178.6
    Conserved Domains (1) summary
    pfam10186
    Location:43 → 388
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55366391..55411830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536563.3 → XP_011534865.1  beclin 1-associated autophagy-related key regulator isoform X1

    See identical proteins and their annotated locations for XP_011534865.1

    UniProtKB/Swiss-Prot
    Q6ZNE5
    Related
    ENST00000558189.1
    Conserved Domains (1) summary
    pfam10186
    Location:1 → 275
    Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49572142..49617561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375578.1 → XP_054231553.1  beclin 1-associated autophagy-related key regulator isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNE5.1 GenPept UniProtKB/Swiss-Prot:Q6ZNE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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